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Is Weekly Iron and Folic Acid Supplementation as Effective as Daily Supplementation for Decreasing Incidence of Anemia in Adolescent Girls?
Arch Pediatr Adolesc Med. 2002;156:128-130.
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THIS CLINICAL TRIAL1 compared the
effectiveness
of weekly vs daily administration of iron plus folic acid for the treatment
of anemia in adolescent Nepalese girls, a population with an extremely high
prevalence of anemia. The study was conducted in a single government-run school
in Dharan, an urban foothill town in Nepal. Girls from the 8th to 12th grades
aged 11 to 18 years were enrolled. Baseline characteristics measured included
sociodemographic variables, diet (vegetarian vs nonvegetarian), history of
parasites, menarcheal status, anthropometrics, and presence of specific physical
abnormalities. The baseline prevalence of anemia in this population was 69%.
Subjects were
randomized to 1 of 3 groups: group A (n = 70) received supplementation
with tablets containing 350 mg of ferrous sulfate and 1.5 mg of folic acid
once a day for 90 to 100 days; group B (n = 67) received the same combination
on a fixed day once a week . . . [Full Text of this Article]QUALITY OF THE STUDY
Randomization of Subjects Accounting for Subjects Blinded Assessment
VALIDITY OF RESULTS
Similarity of Groups
Equal Treatment of Groups Treatment Effect Size Treatment Effect Precision
GENERALIZABILITY
Application of Results to Individual Patients
Cost vs Benefits
CONCLUSIONS
RELATED ARTICLE
Weekly vs Daily Iron and Folic Acid Supplementation in Adolescent Nepalese Girls
Binay Kumar Shah and Piyush Gupta
Arch Pediatr Adolesc Med. 2002;156(2):131-135.
ABSTRACT
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