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Arch Pediatr Adolesc Med. 2002;156:1058.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

I read with interest the commentary on genetic epidemiology and congenital malformation by Hobbs and colleagues in the April issue of the ARCHIVES. It was a nice review and update for a general pediatrician who has been in practice now for 16 years.

However, on page 317, there may have been a mistake in lines 5 and 6, which was repeated in lines 9 and 10. The statement was that "dizygotic twins share half of their genes at most," followed by "dizygotic twins would share the malformation in, at most, 50% of twins studied."

It would seem that the 50% given for dizygotic twins would be an average, as dizygotic twins would have the potential to share from zero to 100% of chromosomes, although either extreme would be incredibly rare.

Jonathan W. Jantz, MD
Wichita Clinic PA, Bethel Office
720 Medical Center Dr
Newton, KS 67114

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