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Reoccurrence of Culture-Positive Pertussis in an Infant Initially Treated With Azithromycin and Steroids
Arch Pediatr Adolesc Med. 2002;156:1057-1058.
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Epidemiologic studies have revealed an increase in the rate of pertussis
infection despite massive vaccination.1-2
Since no curative treatment is available, antibacterial therapy with erythromycin,
40 to 50 mg/kg, 4 times per day for 2 weeks, is recommended in reducing the
length of the illness and in limiting the spread of the infection.3 Newly developed macrolides with improved absorption,
longer half-lives, and fewer adverse effects, combined with encouraging efficacy
trials, have demonstrated the superiority of new macrolides over erythromycin
in upper respiratory tract infections.4
This has led to a switch from erythromycin to the newly available macrolides
for the treatment of pertussis. The superiority of short-term treatment with
the newly developed macrolides over the conventional long-term erythromycin
treatment has been demonstrated.5-6
Report of a Case
A 2-month-old boy was admitted for paroxysmal whooping cough, which
began 1 week before admission. The mother and grandmother complained of a
mild cough and rhinorrhea. Neither apnea nor . . . [Full Text of this Article] Comment
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Treatment failure of nosocomial pertussis infection in a very-low-birth-weight neonate.
Bonacorsi et al.
J. Clin. Microbiol. 2006;44:3830-3832.
ABSTRACT
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Azithromycin Is as Effective as and Better Tolerated Than Erythromycin Estolate for the Treatment of Pertussis
Langley et al.
Pediatrics 2004;114:e96-e101.
ABSTRACT
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