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The Impact of New Diagnostic Tests on the Management of Children With Fever
Arch Pediatr Adolesc Med. 2000;154:761-762.
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RECENTLY POLYMERASE chain reaction (PCR) has been compared with the introduction of the printing press.
Before the advent of movable type, scholarship was greatly hindered by a lack of access to necessary texts. Even a journey to the library of a far-away monastery did not guarantee finding one of the few existing copies of a book, and the volume, once found after a long search, might prove to be a faulty copy produced by a careless scribe. Gutenberg's invention of printing from movable type revolutionized scholarship, leading to an explosion of new knowledge.1
Polymerase chain reaction is similar to the printing press: it exactly reproduces unlimited copies of DNA, thus making a remarkable amount of information available to pediatricians. It is quite likely that within a few years PCR will be available in the office, the emergency department, and at the bedside, thus forever altering how we make clinical decisions. . . . [Full Text of this Article]
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