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Variables Influencing Penicillin Treatment Outcome
Arch Pediatr Adolesc Med. 2000;154:91.
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How good to see the tradition of excellent office-based research on streptococcal illness in Rochester, NY, being continued by Pichichero et al.1 A question comes to mind, however, in reading the article, which evaluates different oral penicillin treatment regimens used to eradicate streptococci in the oropharynx. To what extent might the results have been influenced by whether the penicillin got into the stomachs of the children who were studied? The authors describe an excellent method of assessing adherence to prescribed medications in the "Methods" section, but no results of that assessment are provided.
Several years ago in a study in a hospital clinic, 33 (56%) of 59 children given a 10-day course of oral penicillin had stopped taking the medication by the third day, 42 (71%) by the sixth day, and 48 (82%) by the ninth day.2 Working with 3 private practices in Rochester, probably involving some of the parents . . . [Full Text of this Article]
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