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Laurence Finberg, MD

Arch Pediatr Adolesc Med. 1999;153:910-912.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The following dissertation is derived partially from the literature, is partially a personal memoir, and contains a speculation. I try to answer the question of why oral glucose-electrolyte therapy was so long delayed as a part of the therapeutic armamentarium and why the present formulation of rehydration solutions has taken so long to gain acceptance in the United States. The story begins 268 years ago.

EARLIEST PHYSIOLOGIC THERAPY FOR DEHYDRATION

The recognition of dehydration as a physiologic disturbance affecting circulation could not have been understood until after Harvey's¹ demonstration in 1628 that there was a closed circulation that could be adversely affected. It was 2 centuries later when cholera spread through Europe that William B. O'Shaughnessy, unable to obtain a medical license in London and therefore not allowed to practice medicine, worked in the laboratory doing quantitative analyses on samples of serum and stool water of cholera victims. The results led him . . . [Full Text of this Article]

THE INFLUENCE OF PRODUCT MARKETING
From the University of California, San Francisco; and Stanford University, Stanford, Calif.