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Guides for Reading and Interpreting Systematic Reviews
I. Getting Started
Terry P. Klassen, MD, MSc;
Alejandro R. Jadad, MD, DPhil;
David Moher, MSc
Arch Pediatr Adolesc Med. 1998;152:700-704.
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INTRODUCTION
It is almost impossible for any individual to keep up-to-date with the health care literature. There are approximately 17000 new biomedical books published every year, along with 30000 biomedical journals, resulting in annual increase of 7%.1-2 Physicians attempting to keep abreast of their field would need to read, on average, 19 original articles each day.3 Reviews offer the potential to reach that elusive goal: making life easier.
In the past few years, the ARCHIVES has published systematic reviews on the role of metered-dose inhaler accessory devices compared with nebulizers for the treatment of acute asthma management,4 the efficacy of bronchodilator therapy for bronchiolitis,5 and the behavioral and cognitive effects of methylxanthines.6 These are all complex clinical issues, and for any one clinician to gather and synthesize the evidence would be very time-consuming.
NARRATIVE REVIEWS
Traditionally, individuals often considered experts . . . [Full Text of this Article]
SYSTEMATIC REVIEWS AND META-ANALYSES
ADVANTAGES
LIMITATIONS
POTENTIAL HARMS
DEVELOPING THE QUESTION
DEVELOPING SELECTION CRITERIA
VALIDITY AND SYSTEMATIC REVIEWS
REPLICABILITY AND SYSTEMATIC REVIEWS
SETTING THE STAGE: AN EXAMPLE
CONCLUSIONS
From the Departments of Pediatrics (Dr Klassen and Mr Moher), and Epidemiology and Community Health (Dr Klassen and Mr Moher), University of Ottawa, Thomas C. Chalmers Center for Systematic Reviews, Children's Hospital of Eastern Ontario's Research Institute (Dr Klassen and Mr Moher) Ottawa; and Health Information Research Unit, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton (Dr Jadad) Ontario.
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