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A New Form of Rickets During Infancy
Phosphate Depletion–Induced Osteopenia Due to Antacid Ingestion
Arch Pediatr Adolesc Med. 1998;152:1168-1169.
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IN THIS issue of the ARCHIVES is an important case report describing an infant in whom phosphate depletion due to aluminum and magnesium hydroxide gel therapy (Maalox, Rhone-Poulenc Rorer Pharmaceuticals Inc, Collegeville, Pa) for colic resulted in radiological evidence of rickets and secondary craniosynostosis.1 This article and another recent report of 2 similar cases2 support the conclusion that therapy with phosphate-binding agents can result in the "phosphate depletion syndrome" during infancy.3 Prior to the appearance of these 2 articles, the phosphate depletion syndrome had not been described in infants. This observation of phosphopenia during infancy is particularly noteworthy, because dietary phosphate intake was ample and renal phosphate reclamation was markedly enhanced.4 The resorption of phosphate by the proximal renal tubule of the neonate or infant is so avid that there exists at the tubule a relative resistance to the phosphaturic action of parathyroid hormone. Also, the prevailing concentration of phosphate . . . [Full Text of this Article]
RELATED ARTICLE
Rickets and Secondary Craniosynostosis Associated With Long-term Antacid Use in an Infant
Avinash K. Shetty, Tal Thomas, Jayashree Rao, and Alfonso Vargas
Arch Pediatr Adolesc Med. 1998;152(12):1243-1245.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Calcium and Phosphorous in Pediatric Parenteral Nutrition
Marks and Crill
Journal of Pharmacy Practice 2004;17:432-446.
ABSTRACT
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