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Arch Pediatr Adolesc Med. 1998;152:98-99.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Lorazepam is a benzodiazepine that acts as a -aminobutyric acid (GABA)–receptor agonist. Premature infants have been reported to experience seizurelike activity following the administration of lorazepam.^1-4 We report 2 cases of full-term infants, each without evidence of neurologic disorder, who received lorazepam for sedation and subsequently exhibited a seizurelike activity that occurred shortly after administration and resolved within 1 hour.

Patient Reports

Patient 1

A 2940-g male product of a 40-week gestation that was complicated by thin meconium had Apgar scores of 8 at 1 minute and 9 at 5 minutes. The infant had a clinical illness that was consistent with severe transient tachypnea of the newborn. At 3 hours of age, the infant was intubated for progressive symptoms of transient tachypnea and was given lorazepam (Ativan), 0.1 mg/kg, intravenously for sedation. Within minutes of receiving the medication, the infant had nonsuppressible, clonic jerks of both legs and the right upper extremity. These occurred . . . [Full Text of this Article]

Patient 2

Comment

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pharmacological therapy for analgesia and sedation in the newborn.
Anand and Hall
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