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A Review

PHILLIP E. ROTHMAN, M.D.

AMA Am J Dis Child. 1953;86(2):201-210.

Abstract
THESE introductory sentences which appear in the review by Ingelfinger, Lowell, and Franklin¹ reflect the present status of this form of allergy. Evidence to support this diagnosis has been grouped into three categories: experimental studies, clinical observations, and laboratory tests. A brief summary of their conclusions is helpful in the interpretation of the general aspects of intestinal allergic disorders.

Experimental studies should theoretically be designed to fulfil the following requirements: "Symptoms should be caused by contact with a specific substance that is innocuous to the bulk of the population; an immune mechanism should be evident in their pathogenesis; lesions and functional changes in the gut should be demonstrable." In this respect the work of Walzer and his co-workers² is most informative. They injected serum obtained from a patient highly sensitive to peanuts into the skin of the arm, into the rectal mucosa, and into the intestinal mucosa in

Author Affiliations
BEVERLY HILLS, CALIF.

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