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Erin E. Edmiston, BA; Fei Wang, MD, PhD; Carolyn M. Mazure, PhD; Joanne Guiney, MSc; Rajita Sinha, PhD; Linda C. Mayes, MD; Hilary P. Blumberg, MD

Arch Pediatr Adolesc Med. 2011;165(12):1069-1077. doi:10.1001/archpediatrics.2011.565

Objective  To study the relationship between self-reported exposure to childhood maltreatment (CM) and cerebral gray matter (GM) morphology in adolescents without psychiatric diagnoses.

Design  Associations were examined between regional GM morphology and exposure to CM (measured using a childhood trauma self-report questionnaire for physical, emotional, and sexual abuse and for physical and emotional neglect).

Setting  University hospital.

Participants  Forty-two adolescents without psychiatric diagnoses.

Main Outcome Measures  Correlations between childhood trauma self-report questionnaire scores and regional GM volume were assessed in voxel-based analyses of structural magnetic resonance images. Relationships among GM volume, subtypes of exposure to CM, and sex were explored.

Results  Childhood trauma self-report questionnaire total scores correlated negatively (P < .005) with GM volume in prefrontal cortex, striatum, amygdala, sensory association cortices, and cerebellum. Physical abuse, physical neglect, and emotional neglect were associated with rostral prefrontal reductions. Decreases in dorsolateral and orbitofrontal cortices, insula, and ventral striatum were associated with physical abuse. Decreases in cerebellum were associated with physical neglect. Decreases in dorsolateral, orbitofrontal, and subgenual prefrontal cortices, striatum, amygdala, hippocampus, and cerebellum were associated with emotional neglect. Decreases in the latter emotion regulation regions were also associated with childhood trauma self-report questionnaire scores in girls, while caudate reductions (which may relate to impulse dyscontrol) were seen in boys.

Conclusions  Exposure to CM was associated with corticostriatal-limbic GM reductions in adolescents. Even if adolescents reporting exposure to CM do not present with symptoms that meet full criteria for psychiatric disorders, they may have corticostriatal-limbic GM morphologic alterations that place them at risk for behavioral difficulties. Vulnerabilities may be moderated by sex and by subtypes of exposure to CM.

Author Affiliations: Departments of Psychiatry (Mss Edmiston and Guiney and Drs Wang, Mazure, Sinha, Mayes, and Blumberg) and Diagnostic Radiology (Dr Blumberg) and the Child Study Center (Drs Sinha, Mayes, and Blumberg), Yale University School of Medicine, and the Department of Psychology (Drs Mazure and Mayes), Yale University, New Haven, Connecticut. Ms Edmiston is now with Vanderbilt University, Nashville, Tennessee.

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