• Online Features  This Article  • Full text  • PDF  • eTable  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Pediatrics  • Adolescent Medicine  • Pediatrics, Other  • Statistics and Research Methods  • Prognosis/ Outcomes  • Hematology/ Hematologic Malignancies  • Leukemias/ Lymphomas  • Alert me on articles by topic  Social Bookmarking   What's this?

Eric Tai, MD; Lori A. Pollack, MD; Julie Townsend, MS; Jun Li, MD; C. Brooke Steele, DO; Lisa C. Richardson, MD

Arch Pediatr Adolesc Med. 2010;164(3):218-224.

Objective  To examine differences in non-Hodgkin lymphoma (NHL) survival between young adults and children/adolescents.

Design  Survival analysis using 13 Surveillance, Epidemiology, and End Results registries.

Setting  Cancer survival information from population-based cancer registries from 1992 through 2001.

Participants  A total of 2442 cases of NHL among children/adolescents (aged 0-19 years) and young adults (aged 20-29 years).

Main Exposure  Differences in NHL survival between young adults and children.

Main Outcome Measures  Comparison of 5-year survival by constructing Kaplan-Meier survival curves and modeling 5-year survival with multivariate Cox proportional hazards.

Results  Young adults were more likely to die compared with children/adolescents (hazard ratio = 2.06; 95% confidence interval, 1.65-2.56) even after accounting for NHL subtype and stage at diagnosis. Persons diagnosed with stage III disease (hazard ratio = 1.71; 95% confidence interval, 1.20-2.46) and stage IV disease (hazard ratio = 3.19; 95% confidence interval, 2.47-4.13) were more likely to die compared with persons diagnosed with stage I disease.

Conclusions  Being a young adult at diagnosis and having a higher stage of disease at diagnosis were associated with higher risk of death from NHL. Increasing survival with NHL is dependent on receiving appropriate cancer therapy. Therefore, efforts to address survival should include improving enrollment in clinical trials as well as increasing access to care.

Author Affiliations: Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Malignant hematologic diseases in adolescents and young adults
Wood and Lee
Blood 2011;117:5803-5815.
ABSTRACT | FULL TEXT  

Quality Cancer Care for Adolescents and Young Adults: A Position Statement
Zebrack et al.
JCO 2010;28:4862-4867.
ABSTRACT | FULL TEXT  

Non-Hodgkin Lymphoma Survival Among Adolescents
Tai et al.
Arch Pediatr Adolesc Med 2010;164:779-780.
FULL TEXT