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The AVENA Study

Jonatan R. Ruiz, PhD; Francisco B. Ortega, PhD; Julia Wärnberg, PhD; Luis A. Moreno, MD, PhD; Juan J. Carrero, PhD; Marcela Gonzalez-Gross, PhD; Ascension Marcos, PhD; Angel Gutierrez, MD, PhD; Michael Sjöström, MD, PhD

Arch Pediatr Adolesc Med. 2008;162(5):462-468.

Objectives  To examine the associations between inflammatory proteins and muscle strength and to determine whether this association varies between overweight and nonoverweight adolescents.

Design  Cross-sectional study.

Participants  A total of 416 Spanish adolescents (230 boys and 186 girls) aged 13 to 18 years.

Main Exposures  Muscle strength score was computed as the mean of the handgrip and standing broad jump standardized values. The adolescents were categorized as overweight (including obese) or nonoverweight according to body mass index. Body fat and fat-free mass were derived from skinfold thickness.

Outcome Measures  C-reactive protein, complement factors C3 and C4, ceruloplasmin, and prealbumin levels.

Results  The results of the regression analysis showed that C-reactive protein, C3, and ceruloplasmin were negatively associated with muscle strength after controlling for sex, age, pubertal status, weight, height, socioeconomic status, and cardiorespiratory fitness. Moreover, C-reactive protein and prealbumin levels were associated with muscle strength in overweight adolescents after controlling for potential confounders, including body fat and fat-free mass.

Conclusions  Low-grade inflammation is negatively associated with muscle strength in adolescents. The patterns of these associations seem more relevant in overweight adolescents, suggesting that having high levels of muscle strength may counteract the negative consequences ascribed to body fat.

Author Affiliations: Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum (Drs Ruiz, Ortega, Wärnberg, and Sjöström) and Division of Renal Medicine and Baxter Novum, Department of Clinical Science (Dr Carrero), Karolinska Institutet, Huddinge, Sweden; Department of Physiology, School of Medicine, University of Granada, Granada, Spain (Drs Ruiz, Ortega, and Gutierrez); Immunonutrition Research Group, Department of Metabolism and Nutrition, Consejo Superior de Investigaciones Científicas, Madrid, Spain (Drs Wärnberg and Marcos); Escuela Universitaria Health Sciences, University of Zaragoza, Zaragoza, Spain (Dr Moreno); and School of Sport Sciences, Universidad Politécnica de Madrid, Madrid, Spain (Dr Gonzalez-Gross).

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