This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Adolescent Medicine  • Alert me on articles by topic  Social Bookmarking   What's this?

The AVENA Study

Jonatan R. Ruiz, PhD; Francisco B. Ortega, PhD; Julia Wärnberg, PhD; Luis A. Moreno, MD, PhD; Juan J. Carrero, PhD; Marcela Gonzalez-Gross, PhD; Ascension Marcos, PhD; Angel Gutierrez, MD, PhD; Michael Sjöström, MD, PhD

Arch Pediatr Adolesc Med. 2008;162(5):462-468.

Objectives  To examine the associations between inflammatory proteins and muscle strength and to determine whether this association varies between overweight and nonoverweight adolescents.

Design  Cross-sectional study.

Participants  A total of 416 Spanish adolescents (230 boys and 186 girls) aged 13 to 18 years.

Main Exposures  Muscle strength score was computed as the mean of the handgrip and standing broad jump standardized values. The adolescents were categorized as overweight (including obese) or nonoverweight according to body mass index. Body fat and fat-free mass were derived from skinfold thickness.

Outcome Measures  C-reactive protein, complement factors C3 and C4, ceruloplasmin, and prealbumin levels.

Results  The results of the regression analysis showed that C-reactive protein, C3, and ceruloplasmin were negatively associated with muscle strength after controlling for sex, age, pubertal status, weight, height, socioeconomic status, and cardiorespiratory fitness. Moreover, C-reactive protein and prealbumin levels were associated with muscle strength in overweight adolescents after controlling for potential confounders, including body fat and fat-free mass.

Conclusions  Low-grade inflammation is negatively associated with muscle strength in adolescents. The patterns of these associations seem more relevant in overweight adolescents, suggesting that having high levels of muscle strength may counteract the negative consequences ascribed to body fat.

Author Affiliations: Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum (Drs Ruiz, Ortega, Wärnberg, and Sjöström) and Division of Renal Medicine and Baxter Novum, Department of Clinical Science (Dr Carrero), Karolinska Institutet, Huddinge, Sweden; Department of Physiology, School of Medicine, University of Granada, Granada, Spain (Drs Ruiz, Ortega, and Gutierrez); Immunonutrition Research Group, Department of Metabolism and Nutrition, Consejo Superior de Investigaciones Científicas, Madrid, Spain (Drs Wärnberg and Marcos); Escuela Universitaria Health Sciences, University of Zaragoza, Zaragoza, Spain (Dr Moreno); and School of Sport Sciences, Universidad Politécnica de Madrid, Madrid, Spain (Dr Gonzalez-Gross).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents
Wamba et al.
Eur J Endocrinol 2008;159:781-790.
ABSTRACT | FULL TEXT  

Clinical Measures of Physical Fitness Predict Insulin Resistance in People at Risk for Diabetes
Chen et al.
ptjournal 2008;88:1355-1364.
ABSTRACT | FULL TEXT