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Polymorphisms for Interleukin 1ß Exon 5 and Interleukin 1 Receptor Antagonist in Taiwanese Children With Febrile Convulsions
Fuu-Jen Tsai, MD, PhD;
Yao-Yuan Hsieh, MD;
Chi-Chen Chang, MD;
Cheng-Chieh Lin, MD;
Chang-Hai Tsai, MD, PhD
Arch Pediatr Adolesc Med. 2002;156:545-548.
Objective To investigate whether interleukin 1ß (IL-1ß) exon 5 and IL-1
receptor antagonist (IL-1Ra) gene polymorphisms can be used as markers of
susceptibility to febrile convulsions in children.
Methods Children were divided into 2 groups: those with febrile convulsions
(group 1; n = 51) and normal control subjects (group 2; n = 83). Polymorphisms
for IL-1ß exon 5 and IL-1Ra gene polymorphisms were detected by polymerase
chain reaction. Genotypes and allelic frequencies for IL-1ß exon 5 and
IL-1Ra gene polymorphisms in both groups were compared.
Results Genotype and allele frequencies for IL-1ß exon 5 in both groups
were not significantly different. Proportions of E1
homozygotes and E1/E2 heterozygotes for IL-1ß
exon 5 were 50 (98.1%) and 1 (1.9%), respectively, in group 1 and 82 (98.8%)
and 1 (1.2%), respectively, in group 2. Frequencies of alleles E1 and E2 for IL-1ß exon 5 were 101 (99.0%)
and 1 (1.0%), respectively, in group 1 and 165 (99.4%) and 1 (0.6%), respectively,
in group 2. Genotype proportions and allele frequencies for IL-1Ra between
groups were significantly different. Proportions of genotypes I/I and I/II for IL-1Ra were 49 (96.1%) and
2 (3.9%) in group 1 and 69 (83.1%) and 14 (16.9%) in group 2. Frequencies
of alleles I and II for
IL-1Ra were 100 (98.0%) and 2 (2.0%) in group 1 and 152 (91.6%) and 14 (8.4%)
in group 2.
Conclusions The IL-1Ra allele I is associated with a higher susceptibility to febrile
convulsion, which may become a useful marker for predicting the development
of febrile convulsions. The IL-1ß exon 5 gene polymorphisms are not a
useful marker for predicting the susceptibility to febrile convulsions.
From the Departments of Pediatrics and Medical Genetics (Drs F.-J.
Tsai and C.-H. Tsai), Obstetrics and Gynecology (Drs Hsieh and Chang), and
Family Medicine (Dr Lin), China Medical College Hospital, Taichung, Taiwan.
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