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Long-term Consequences of Kawasaki Disease Among First-Year Junior High School Students
Shizuhiro Hirata, MD;
Yosikazu Nakamura, MD, MPH, FFPHM;
Kozo Matsumoto, MD;
Hiroshi Yanagawa, MD, FFPHM
Arch Pediatr Adolesc Med. 2002;156:77-80.
Objective To determine whether height, weight, and electrocardiographic (ECG)
abnormalities differ at the age of 13 years between adolescents with and without
Kawasaki disease (KD) (also known as mucocutaneous lymph node syndrome).
Design A population-based cohort study.
Setting School community and public health service.
Methods Data from the nationwide surveys of KD in Japan were linked with those
of junior high school cardiac screening in Tochigi Prefecture between April
1, 1986, and June 30, 1998 (except data for 1988 and 1994). Using this database,
students with KD and students without KD in the first year of junior high
school were compared.
Main Outcome Measures Height, weight, and ECG abnormalities.
Results Eight hundred sixty students (486 adolescent boys and 374 adolescent
girls) with KD and 308 729 students (158 193 adolescent boys and
150 536 adolescent girls) without KD were located. There was no difference
in average height and weight between the students with and without KD (using
the P values for a t test
of the means). The proportion of abnormal ECG findings was 10% and 3% among
those with and without KD, respectively.
Conclusion Even at age 13 years, the proportion of abnormal ECG findings was about
3 times higher among adolescents with KD (using a  2 test of
the difference in 2 binomial proportions).
From the Department of Public Health, Jichi Medical School (Drs Hirata
and Nakamura), and the Tochigi Medical Association (Dr Matsumoto), Tochigi,
Japan; and the Saitama Prefectural University, (Dr Yanagawa) Saitama, Japan.
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