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W. James King, MD, FRCPC; Anne Schlieper, PhD; Nina Birdi, MD; Mario Cappelli, PhD; Yolanda Korneluk, BA; Peter C. Rowe, MD

Arch Pediatr Adolesc Med. 2000;154:463-468.

Objective  To determine whether there are associated long-term deficits in the cognitive, academic, or behavioral outcomes of children with a previous episode of Kawasaki disease.

Design  Cohort analytic study.

Setting  A tertiary care pediatric hospital in Ottawa, Ontario.

Participants  Thirty-two patients with a past diagnosis of Kawasaki disease. Siblings of the patients with Kawasaki disease were eligible to be controls.

Measures  A blinded psychometrist (Y.K.) assessed cognition by the appropriate Wechsler Intelligence scale, academic achievement by the Wechsler Individual Achievement Test, and behavior by the Achenbach Child Behavior Checklist.

Results  No differences were found in cognitive or academic measures and the mean scores corresponded closely to national norms. Parents rated their children who had Kawasaki disease as having significantly more internalizing (P<.03) and attentional (P<.02) behavior problems than controls; the risk of a clinically significant behavioral score was 3.3 times greater (P<.03; 95% confidence interval, 1.1-9.9) than for sibling controls.

Conclusions  While no effect on cognitive development or academic performance was demonstrated, these results provide preliminary indication of a post–Kawasaki disease deficit in internalizing and attentional behavior.

From the Departments of Pediatrics (Drs King and Birdi) and Psychology (Drs Schlieper and Cappelli and Ms Korneluk), Children's Hospital of Eastern Ontario, University of Ottawa; and the Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Md (Dr Rowe).

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