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Treatment of Sialorrhea With Glycopyrrolate
A Double-blind, Dose-Ranging Study
Richard J. Mier, MD;
Steven J. Bachrach, MD;
Ryan C. Lakin, MS;
Tara Barker, BS;
Judith Childs, PhD;
Maria Moran, MS
Arch Pediatr Adolesc Med. 2000;154:1214-1218.
Objective To determine the safety and efficacy of glycopyrrolate in the treatment of developmentally disabled children with sialorrhea.
Design Placebo-controlled, double-blind, crossover dose-ranging study.
Setting Outpatient facilities in 2 pediatric hospitals.
Patients Thirty-nine children with both developmental disabilities and excessive and bothersome sialorrhea.
Main Outcome Measures Parent and investigator evaluation of change in sialorrhea and adverse effects.
Results Glycopyrrolate in doses of 0.10 mg/kg per dose is effective at controlling sialorrhea. Even at low doses, 20% of children may exhibit adverse effects severe enough to require discontinuation.
Conclusions Glycopyrrolate is effective in the control of excessive sialorrhea in children with developmental disabilities. Approximately 20% of children given glycopyrrolate may experience substantial adverse effects, enough to require discontinuation of medication.
From the Shriners Hospital for Children, Lexington, Ky (Dr Mier, Mr Lakin, and Ms Barker), and the Alfred I. duPont Hospital for Children, Wilmington, Del (Drs Bachrach and Childs and Ms Moran).
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