You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 152 No. 11, November 1998 TABLE OF CONTENTS
  Archives
  •  Online Features
  Article
 This Article
 •Full text
 •PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (29)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Topic Collections
 •Viral Infections
 •Adolescent Medicine
 •Gastroenterology
 •Liver/ Biliary Tract/ Pancreatic Diseases
 •Infectious Diseases
 •Alert me on articles by topic
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Minocycline-Related Autoimmune Hepatitis

Case Series and Literature Review

Jonathan E. Teitelbaum, MD; Antonio R. Perez-Atayde, MD; Mark Cohen, MD; Athos Bousvaros, MD; Maureen M. Jonas, MD

Arch Pediatr Adolesc Med. 1998;152:1132-1136.

Background  Minocycline is an antibiotic commonly used in the treatment of adolescent acne.

Objectives  To describe the clinical, laboratory, and histological features in 3 cases of minocycline-related autoimmune hepatitis and to review the literature of similar cases in the adolescent population.

Design  Case series.

Setting  Patients were cared for in the Division of Gastroenterology, Children's Hospital, Boston, Mass.

Results  Three adolescents (age, 15-16 years), while being treated with therapeutic doses of minocycline for periods of 12 to 20 months, met the 1993 International Autoimmune Hepatitis Group criteria for autoimmune hepatitis. All had a positive antinuclear antibody titer. Other features included hypergammaglobulinemia and a positive anti–smooth muscle antibody titer. Two patients underwent liver biopsy that revealed severe chronic lymphoplasmacytic inflammation, necrosis, and fibrosis. All other causes of liver disease were excluded. One patient had resolution of symptoms with withdrawal of the drug, while 2 required immunosuppression therapy. A review of the literature yielded only 18 similar cases, none in the pediatric literature, the majority of which contained incomplete pertinent data.

Conclusions  Minocycline is related to the development of autoimmune hepatitis in some adolescents. Pediatricians who use this drug for treatment of acne should be aware of this serious potential relation and stop the drug immediately when suspicion is raised.

Arch Pediatr Adolesc Med. 1998;152:1132-1136


From the Combined Program in Gastroenterology and Nutrition (Drs Teitelbaum, Bousvaros, and Jonas) and the Department of Pathology (Dr Perez-Atayde), Children's Hospital, Harvard Medical School, Boston, Mass; and Acton Medical Associates, Acton, Mass (Dr Cohen).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Bioactivation of Minocycline to Reactive Intermediates by Myeloperoxidase, Horseradish Peroxidase, and Hepatic Microsomes: Implications for Minocycline-Induced Lupus and Hepatitis
Mannargudi et al.
Drug Metab. Dispos. 2009;37:1806-1818.
ABSTRACT | FULL TEXT  

Doxycycline Influences Microcirculation Patterns in B16 Melanoma
Sun et al.
Exp. Biol. Med. 2007;232:1300-1307.
ABSTRACT | FULL TEXT  

Minocycline-Induced Pancreatitis in Cystic Fibrosis
Boyle
Chest 2001;119:1283-1285.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1998 American Medical Association. All Rights Reserved.