 |
|
Garlic Extract Therapy in Children With Hypercholesterolemia
Brian W. McCrindle, MD, MPH, FRCPC;
Elizabeth Helden, BSN, MEd;
William T. Conner, MBBS, MRCP, FRCPC
Arch Pediatr Adolesc Med. 1998;152:1089-1094.
Objective To determine whether garlic extract therapy is efficacious and safe in children with hypercholesterolemia.
Design Randomized, double-blind, placebo-controlled clinical trial.
Setting Specialized pediatric lipid disorders ambulatory clinic.
Participants Thirty pediatric patients, aged 8 to 18 years, who had familial hyperlipidemia and a minimum fasting total cholesterol level greater than 4.8 mmol/L (>185 mg/dL).
Intervention An 8-week course of a commercially available garlic extract (Kwai [Lichtwer Pharma, Berlin, Germany], 300 mg, 3 times a day) or an identical placebo.
Main Outcome Measures Absolute and relative changes in fasting lipid profile parameters.
Results The groups were equivalent at baseline and compliance was similar in the 2 groups (P=.45). There was no significant relative attributable effect of garlic extract on fasting total cholesterol (+0.6% [95% confidence interval, -5.8% to +6.9%]) or low-density lipoprotein cholesterol (-0.5% [95% confidence interval, -8.7% to +7.6%]). The lower limits of the confidence intervals did not include -10%, the minimum relative attributable effect believed to be clinically important. Likewise, no significant effect was seen on the levels of high-density lipoprotein, triglycerides, apolipoprotein B-100, lipoprotein(a), fibrinogen, homocysteine, or blood pressure. There was a small effect on apolipoprotein A-I (+10.0% [95% confidence interval, +1.2% to +16.5%] P=.03). There were no differences in adverse effects between groups.
Conclusion Garlic extract therapy has no significant effect on cardiovascular risk factors in pediatric patients with familial hyperlipidemia.
From the Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, (Dr McCrindle); and the Department of Pediatrics, McMaster University, St Joseph's Hospital, Hamilton, Ontario (Ms Helden and Dr Conner).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Review: Management of dyslipidemia in children and adolescents with systemic lupus erythematosus
Ardoin et al.
Lupus 2007;16:618-626.
ABSTRACT
Screening and Treatment for Lipid Disorders in Children and Adolescents: Systematic Evidence Review for the US Preventive Services Task Force
Haney et al.
Pediatrics 2007;120:e189-e214.
ABSTRACT
| FULL TEXT
Screening for Lipid Disorders in Children: US Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force
Pediatrics 2007;120:e215-e219.
FULL TEXT
Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents: A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, With the Council on Cardiovascular Nursing
McCrindle et al.
Circulation 2007;115:1948-1967.
ABSTRACT
| FULL TEXT
Effect of Raw Garlic vs Commercial Garlic Supplements on Plasma Lipid Concentrations in Adults With Moderate Hypercholesterolemia: A Randomized Clinical Trial
Gardner et al.
Arch Intern Med 2007;167:346-353.
ABSTRACT
| FULL TEXT
Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics
Kavey et al.
Circulation 2006;114:2710-2738.
ABSTRACT
| FULL TEXT
Complementary, Holistic, and Integrative Medicine: Garlic
Shamseer et al.
Pediatr. Rev. 2006;27:e77-e80.
FULL TEXT
Gender May Affect the Action of Garlic Oil on Plasma Cholesterol and Glucose Levels of Normal Subjects
Zhang et al.
J. Nutr. 2001;131:1471-1478.
ABSTRACT
| FULL TEXT
Garlic Shows Promise for Improving Some Cardiovascular Risk Factors
Ackermann et al.
Arch Intern Med 2001;161:813-824.
ABSTRACT
| FULL TEXT
Intake of Garlic and Its Bioactive Components
Amagase et al.
J. Nutr. 2001;131:955S-962.
ABSTRACT
| FULL TEXT
Garlic for Treating Hypercholesterolemia: A Meta-Analysis of Randomized Clinical Trials
Stevinson et al.
ANN INTERN MED 2000;133:420-429.
ABSTRACT
| FULL TEXT
Herbs in Pediatric and Adolescent Medicine
Gardiner and Kemper
Pediatr. Rev. 2000;21:44-57.
FULL TEXT
|
