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The Penn State Young Women's Health Study

Tom Lloyd, PhD; Vernon M. Chinchilli, PhD; Douglas F. Eggli, MD; Nan Rollings, MEd RN; Howard E. Kulin, MD

Arch Pediatr Adolesc Med. 1998;152:998-1002.

Objective  To obtain simultaneous and longitudinal measures of height, weight, total body bone mineral content, total body bone mineral density, percentage of body fat, lean body mass, and body mass index in healthy white females between the ages of 11 and 18 years.

Design  A longitudinal, observational study.

Setting  University medical center in a small city.

Study Participants  At initiation in 1990, 112 premenarchal, healthy girls were enrolled. Results presented in this report are based on measurements made on the 82 participants who remained in the study in 1996 and for whom we had comprehensive measurements.

Interventions  None.

Main Outcome Measures  Dual-energy x-ray absorptiometry was used to obtain measurements of total body bone mineral content, total body bone mineral density, percentage of body fat, and lean body mass every 6 months for the first 4 years of the study and yearly thereafter.

Results  The mean age for peak velocity and peak accumulation for each measurement was as follows: height, 11 and 17 years, respectively; weight, 11 and 17 years; body mass index, 11 and 17 years; percentage of body fat, 11 and 13 years; lean body mass, 12 and 17 years; total body bone mineral content, 13 and 17 years; and total body bone mineral density, 13 and 17 years.

Conclusions  Among a healthy population of white females, the age of peak velocities for height, weight, body fat, and lean body mass occur at 11 to 12 years. Thus, peak soft-tissue velocities precede hard-tissue velocities by about 2 years, with peak accumulation of all tissue components being reached, on average, by age 17 years.

From the Departments of Health Evaluation Sciences (Drs Lloyd and Chinchilli and Ms Rollings), Radiology (Dr Eggli), and Pediatrics (Dr Kulin), The College of Medicine and University Hospitals, The Pennsylvania State University at The Milton S. Hershey Medical Center, Hershey.

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