You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 151 No. 4, April 1997 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Birth defects and childhood cancer in offspring of survivors of childhood cancer

D. M. Green, A. Fiorello, M. A. Zevon, B. Hall and N. Seigelstein
Department of Pediatrics, Roswell Park Cancer Institute, Buffalo, NY, USA.

OBJECTIVE: To determine the effect of chemotherapy for cancer during childhood and adolescence on subsequent pregnancy outcome and the occurrence of cancer in the offspring. DESIGN: We reviewed the history of 405 former patients with pediatric cancer. A self-administered questionnaire was completed by members of a cohort of consecutively treated patients who were aged 18 years or older at the most recent follow-up visit and who were at least 5 years beyond the initial diagnosis of their cancer. SETTING: Department of Pediatrics of a National Cancer Institute-designated comprehensive cancer center. RESULTS: One hundred forty-eight patients reported 280 pregnancies. Ninety-one of the patients who reported 1 or more liveborn or stillborn infants following the completion of treatment had received 1 or more chemotherapeutic agents as part of their treatment of cancer. The frequency of congenital anomalies was 3.3% among the liveborn offspring of the treated women and 3.3% among the liveborn offspring of the spouses or female companions of the treated men. No cases of childhood cancer have been diagnosed among the offspring. CONCLUSIONS: The present data suggest that prior treatment with mutagenic chemotherapeutic agents, in the dosage ranges examined, does not increase the frequency of congenital anomalies in the offspring of former pediatric and adolescent patients with cancer. Although no cases of childhood cancer have been observed thus far among the offspring, additional follow-up is necessary to adequately assess their risk of childhood cancer.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pregnancy Outcomes in Survivors of Childhood Cancer
Nagarajan and Robison
J Natl Cancer Inst Monogr 2005;2005:72-76.
ABSTRACT | FULL TEXT  

Preserving the reproductive potential of men and boys with cancer: current concepts and future prospects
Tournaye et al.
Hum Reprod Update 2004;10:525-532.
ABSTRACT | FULL TEXT  

Pregnancy Outcome of Partners of Male Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
Green et al.
JCO 2003;21:716-721.
ABSTRACT | FULL TEXT  

Pregnancy Outcome After Treatment for Wilms Tumor: A Report From the National Wilms Tumor Study Group
Green et al.
JCO 2002;20:2506-2513.
ABSTRACT | FULL TEXT  

Postchemotherapy Ejaculatory Azoospermia: Fatherhood With Sperm From Testis Tissue With Intracytoplasmic Sperm Injection
Damani et al.
JCO 2002;20:930-936.
ABSTRACT | FULL TEXT  

Fertility and Pregnancy Outcome after Treatment for Cancer in Childhood or Adolescence
Green
The Oncologist 1997;2:171-179.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1997 American Medical Association. All Rights Reserved.