This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Peter A. Lee, MD, PhD

Arch Pediatr Adolesc Med. 1994;148(4):369-376.

Abstract
It is necessary not only to perform laboratory tests for the correct diagnosis of children with precocious puberty, but also to monitor laboratory tests to ensure adequacy of therapy. Careful laboratory testing is a requisite in the differentiation of central from peripheral precocious puberty. It is also required to determine whether the patient who presents with early physical changes of pubertal development with peripheral precocious puberty has evidence of pubertal hormonal secretion. The most useful single test is gonadotropin-releasing hormone (gonadorelin) stimulation of luteinizing hormone release. The same stimulation test is also indicated to verify the adequacy of suppression of gonadotropin secretion among patients with central precocious puberty who are being treated with gonadotropin-releasing hormone analogue. It is necessary to know which gonadotropin assay is being used and the range of nomal levels to correctly interpret the tests.

(Arch Pediatr Adolesc Med. 1994;148:369-376)

Author Affiliations
From the Department of Pediatrics, University of Pittsburgh (Pa) School of Medicine.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Factors Determining Normal Adult Height in Girls with Gonadotropin-Dependent Precocious Puberty Treated with Depot Gonadotropin-Releasing Hormone Analogs
Brito et al.
J. Clin. Endocrinol. Metab. 2008;93:2662-2669.
ABSTRACT | FULL TEXT  

Assessment of Basal and Gonadotropin-Releasing Hormone-Stimulated Gonadotropins by Immunochemiluminometric and Immunofluorometric Assays in Normal Children
Resende et al.
J. Clin. Endocrinol. Metab. 2007;92:1424-1429.
ABSTRACT | FULL TEXT  

Performance Characteristics of a Novel Tandem Mass Spectrometry Assay For Serum Testosterone
Kushnir et al.
Clin. Chem. 2006;52:120-128.
ABSTRACT | FULL TEXT  

A Single Luteinizing Hormone Determination 2 Hours after Depot Leuprolide Is Useful for Therapy Monitoring of Gonadotropin-Dependent Precocious Puberty in Girls
Brito et al.
J. Clin. Endocrinol. Metab. 2004;89:4338-4342.
ABSTRACT | FULL TEXT  

Testosterone Measured by 10 Immunoassays and by Isotope-Dilution Gas Chromatography-Mass Spectrometry in Sera from 116 Men, Women, and Children
Taieb et al.
Clin. Chem. 2003;49:1381-1395.
ABSTRACT | FULL TEXT  

Diagnostic Value of Fluorometric Assays in the Evaluation of Precocious Puberty
Brito et al.
J. Clin. Endocrinol. Metab. 1999;84:3539-3544.
ABSTRACT | FULL TEXT  

Prevention of Bone Demineralization by Calcium Supplementation in Precocious Puberty during Gonadotropin-Releasing Hormone Agonist Treatment
Antoniazzi et al.
J. Clin. Endocrinol. Metab. 1999;84:1992-1996.
ABSTRACT | FULL TEXT  

Treatment of gonadotropin dependent precocious puberty due to hypothalamic hamartoma with gonadotropin releasing hormone agonist depot
de Brito et al.
Arch. Dis. Child. 1999;80:231-234.
ABSTRACT | FULL TEXT