This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Follow-up

Marciano Sanchez-Bayle, MD; Angel Gonzalez-Requejo, MD; Jose Baeza, MD; Pilar Arnaiz, MD; Santiago Vila, MD; J. Asensio, MD; C. Ruiz-Jarabo, PhD

Arch Pediatr Adolesc Med. 1994;148(1):28-32.

Abstract
Objective
To determine the effectiveness and compliance of dietary restriction in a group of children and adolescents with hypercholesterolemia.

Research Design
Prospective clinical trial.

Setting
Pediatric hospital in Madrid, Spain.

Participants
Four hundred fifty-one children and adolescents of both sexes aged 2 to 18 years diagnosed as having hypercholesterolemia and treated with dietary restriction (American Heart Association StepOne and Step-Two Diets). The follow-up period ranged from 6 months to 2 years and was performed by one pediatrician.

Results
Total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B-100 levels as well as the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio decreased significantly (P<.01) from the first month of dietary restriction, whereas the high-density lipoprotein cholesterol level increased (P<.01). The apolipoprotein A-I level increased significantly (P<.01) only after 6 months of diet therapy. After 12 months of follow-up, 30.7% (58/189) of patients did not follow the diet strictly. In this group, significantly higher levels of total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B-100 were found.

Conclusions
Diet therapy is effective in the treatment of hypercholesterolemia in children and adolescents. Dietary restriction has a beneficial effect not only on total cholesterol and low-density lipoprotein cholesterol levels but also on apolipoprotein A-I and B-100 levels.

(Arch Pediatr Adolesc Med. 1994;148:28-32)

Author Affiliations
From the Hospital del Niño Jesus, Madrid, Spain.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Screening and Treatment for Lipid Disorders in Children and Adolescents: Systematic Evidence Review for the US Preventive Services Task Force
Haney et al.
Pediatrics 2007;120:e189-e214.
ABSTRACT | FULL TEXT  

The Effect of Fiber Supplementation on Lipid Profile in Children with Hypercholesterolemia
Sanchez-Bayle et al.
CLIN PEDIATR 2001;40:291-294.
 

Immunization Status as Determined by Patients' Hand-Held Cards vs Medical Records
Fierman et al.
Arch Pediatr Adolesc Med 1996;150:863-866.
ABSTRACT  

Who Needs an Immunization in a Pediatric Subspecialty Clinic?
Basco et al.
Arch Pediatr Adolesc Med 1996;150:508-511.
ABSTRACT