Uses of nonsteroidal anti-inflammatory drugs in pediatrics
C. B. Lindsley
Department of Pediatrics, University of Kansas Medical Center, Kansas City 66160-7330.
Nonsteroidal anti-inflammatory drugs have an expanding role in pediatrics.
The indications include (1) treatment of childhood rheumatic disease and
other chronic inflammatory conditions; (2) symptomatic treatment of
clinical problems such as fever, musculoskeletal pain, or dysmenorrhea; and
(3) induction of closure of patent ductus arteriosus. Nonsteroidal
anti-inflammatory drugs are generally well tolerated with a low incidence
of serious side effects. However, potentially serious gastrointestinal,
hepatic, central nervous system, and renal adverse effects have occurred.
The pediatrician should be familiar with the pharmacokinetics and dosages
of the various nonsteroidal anti-inflammatory drugs as well as laboratory
tests necessary to monitor their use. Guidelines are suggested.
