This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Reanalysis

Laura E. Mitchell, PhD; Neil Risch, PhD

Am J Dis Child. 1993;147(11):1203-1211.

Abstract
• Objective.
—To determine whether the existing family data for infantile hypertrophic pyloric stenosis (IHPS) are sufficient for the purposes of establishing the mode of inheritance of this condition.

Design.
—Reanalysis of the familial aggregation patterns exhibited by IHPS, using data from several published family studies.

Conclusions.
—Due to several limitations of the available family data for IHPS, the results of this analysis should be interpreted cautiously. Within the context of these limitations, the familial recurrence pattern among monozygotic cotwins and more remote relatives of IHPS probands was found to be inconsistent with generalized single major locus inheritance. The familial recurrence pattern of IHPS is, however, compatible with multifactorial threshold inheritance or the effects of multiple interacting loci. Under a model of multiple interacting loci, no single locus can account for more than a fivefold increase in the risk to first-degree relatives of IHPS probands. In contrast to several earlier reports, this analysis does not support the existence of a maternal factor that contributes to the risk of IHPS in the offspring of affected females.

(AJDC. 1993;147:1203-1211)

Author Affiliations
From the Division of Biostatistics, Washington University School of Medicine, St Louis, Mo (Dr Mitchell); and the Departments of Epidemiology and Public Health and Genetics, Yale University School of Medicine, New Haven, Conn (Dr Risch).

Footnotes
Accepted for publication July 16, 1993.

Reprint requests to Division of Biostatistics, Washington University School of Medicine, Box 8067, 660 S Euclid Ave, St Louis, MO 63110 (Dr Mitchell).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis
Saur et al.
Proc. Natl. Acad. Sci. USA 2004;101:1662-1667.
ABSTRACT | FULL TEXT  

Infantile Hypertrophic Pyloric Stenosis
Hernanz-Schulman
Radiology 2003;227:319-331.
ABSTRACT | FULL TEXT  

Delineation of a new syndrome: clustering of pyloric stenosis, endometriosis, and breast cancer in two families
LIEDE et al.
J. Med. Genet. 2000;37:794-796.
FULL TEXT  

Molecular cytogenetic characterisation of partial trisomy 9q in a case with pyloric stenosis and a review
Heller et al.
J. Med. Genet. 2000;37:529-532.
ABSTRACT | FULL TEXT  

Case 26-1999- A Three-Week-Old Girl with Pyloric Stenosis and an Unexpected Operative Finding
Lund and Compton
NEJM 1999;341:679-684.
FULL TEXT