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  Vol. 147 No. 1, January 1993 TABLE OF CONTENTS
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Which child will have a febrile seizure?

P. Bethune, K. Gordon, J. Dooley, C. Camfield and P. Camfield
Izaak Walton Killam Children's Hospital, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia.

OBJECTIVE--To identify risk factors predictive of a first febrile seizure. DESIGN--Case-control study. SETTING--Regional referral pediatric hospital emergency department. PATIENTS--Seventy-five patients aged 6 months to 4 years presenting with a first febrile seizure were age-matched to two febrile and two afebrile noninfectious controls who had never had a seizure. METHODS--Telephone interview of parents. MAIN OUTCOME MEASURES--Risk factors assessed included family history of febrile or afebrile seizures, neurodevelopmental abnormality, and child-care arrangement. Analysis was done by matched case-control and logistic regression. RESULTS--Factors associated with a significant increase in risk of a first febrile seizure were febrile seizures in first-degree relative (odds ratio [OR], 4.5) or second-degree relative (OR, 3.5); neonatal discharge at 28 days or later (OR, 5.6); parental report of "slow" development (OR, 4.9); and day-care attendance (OR, 3.1). For children with two risk factors (an estimated 3% of the population), the risk of developing febrile seizures is approximately 28% (assuming a population incidence of febrile seizures of 4%).

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