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Peggy Bethune, MD; Kevin Gordon, MD, MS; Joseph Dooley, MB; Carol Camfield, MD; Peter Camfield, MD

Am J Dis Child. 1993;147(1):35-39.

Abstract
• Objective.
—To identify risk factors predictive of a first febrile seizure.

Design.
—Case-control study.

Setting.
—Regional referral pediatric hospital emergency department.

Patients.
—Seventy-five patients aged 6 months to 4 years presenting with a first febrile seizure were age-matched to two febrile and two afebrile noninfectious controls who had never had a seizure.

Methods.
—Telephone interview of parents.

Main Outcome Measures.
—Risk factors assessed included family history of febrile or afebrile seizures, neurodevelopmental abnormality, and child-care arrangement. Analysis was done by matched case-control and logistic regression.

Results.
—Factors associated with a significant increase in risk of a first febrile seizure were febrile seizures in first-degree relative (odds ratio [OR], 4.5) or second-degree relative (OR, 3.5); neonatal discharge at 28 days or later (OR, 5.6); parental report of "slow" development (OR, 4.9); and day-care attendance (OR, 3.1). For children with two risk factors (an estimated 3% of the population), the risk of developing febrile seizures is approximately 28% (assuming a population incidence of febrile seizures of 4%).

(AJDC. 1993;147:35-39)

Author Affiliations
From the Izaak Walton Killam Children's Hospital, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia.

Footnotes
Accepted for publication August 23, 1992.

Presented as a poster at the Child Neurology Society Meeting, Portland, Ore, October 3, 1991.

Reprint requests to Izaak Walton Killam Children's Hospital, 5850 University Ave, Box 3070, Halifax, Nova Scotia, Canada B3J 3G9 (Dr Gordon).

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