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Cristian J. Garcia, MD; Alan Daneman, MB, FRCPC; Paul Thorner, MD; Denis Daneman, MB, FRCPC

Am J Dis Child. 1992;146(7):811-816.

Abstract
• Multinodular disease of the thyroid gland is uncommon in children and adolescents, and has received little attention in the recent literature. This article reviews the clinical, sonographic, and pathologic findings in 16 children with multinodular disease of the thyroid gland, and draws attention to the high incidence of other associated clinical findings. This condition was associated with a triad including renal and digital anomalies in three patients, with McCune-Albright syndrome in two patients, with Hashimoto's thyroiditis in three patients, and with thyroid carcinoma in four patients. Three of five patients with a history of previous radiation therapy had thyroid carcinoma. Sonography is a proven valuable imaging modality for the study of thyroid disease in children and has contributed to our understanding of multinodular disease of the thyroid gland in this age group.

(AJDC. 1992;146:811-816)

Author Affiliations
From the Departamento Radiologia, Hospital Clinico Universidad Catolica, Santiago, Chile (Dr Garcia), and the Departments of Diagnostic Imaging (Dr Garcia and Mr A. Daneman), Pathology (Dr Thorner), and Endocrinology (Mr D. Daneman), The Hospital for Sick Children, Toronto, Ontario.

Footnotes
Accepted for publication December 8, 1991.

Presented as a poster at the International Paediatric Radiology Meeting in Stockholm, May 29, 1991.

Reprint requests to Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada, M5G IX8 (Dr A. Daneman).

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