Immunogenicity and reactogenicity of Takeda acellular pertussis-component diphtheria-tetanus-pertussis vaccine in 2- and 3-month-old children in Japan
H. Kamiya, R. Nii, T. Matsuda, N. Yasuda, P. D. Christenson and J. D. Cherry
Mie National Hospital, Tsu, Japan.
OBJECTIVE--To compare the reactogenicity and immune response to the Takeda
acellular pertussis-component diphtheria-tetanus-pertussis (APDT) vaccine
in children when immunization commenced at 2 months (group A) vs 3 months
(group B) of age. DESIGN--Longitudinal, nonblinded, comparative study.
SETTING--Pediatric well-child clinics. PARTICIPANTS--Healthy 50- to
98-day-old infants. RESULTS--Good antibody responses to
lymphocytosis-promoting factor, filamentous hemagglutinin, agglutinogens,
and pertactin occurred in both age groups after both the third and fourth
vaccine doses. Both young age and transplacentally acquired maternal
antibody independently and together have a suppressive effect on the
response to the four antigens in this APDT vaccine. However, these effects
appear to be minor. Vaccine reactions were mild; group A children had
slightly but not significantly higher rates than group B children.
CONCLUSION--The present US diphtheria and tetanus toxoids and pertussis
vaccine immunization schedule should also be satisfactory with this
acellular pertussis component vaccine.
