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Sanford Anderson, MD; John Fangman, MD; Gael Wager, MD; Donald Uden, PharmD

Am J Dis Child. 1992;146(1):36-39.

Abstract
• From August 1988 to October 1989, 60 specimens of citrate-phosphate-dextrose-adenine anticoagulated blood were retrieved from the placental umbilical veins of newborns from three gestational age groups. The specimens were removed with a needle and syringe apparatus and placed directly into sterile transfusion packs. The specimens were evaluated for the volume obtained, sterility, and presence of macroscopic clots. A blood volume sufficient to provide at least one transfusion (10 mL/kg) for 87% of the premature infants studied was retrieved from the placenta. A greater blood volume per unit of birth weight was recovered from the placentas of the smaller newborns. A 12% positive culture frequency and a 7% frequency of detectable clots were identified. These rates of occurrence suggest the need for further studies to determine the origins of these complicating factors before the adoption of this technique in the clinical setting. These findings support the hypothesis that, with proper patient selection and with specimen culture and filtration, placental blood may be a viable option for the autologous transfusion of sick, premature infants. (AJDC. 1992;146:36-39)

Author Affiliations
From the Departments of Pediatrics and Neonatology, Minneapolis (Minn) Children's Medical Center (Drs Anderson, Fangman, and Uden), the Department of Perinatology, Abbott Northwestern Hospital (Dr Wager), and the College of Pharmacy, University of Minnesota, Minneapolis (Dr Uden).

Footnotes
Accepted for publication September 12, 1991.

Reprint requests to 2525 Chicago Ave S, Minneapolis, MN 55404 (Dr Anderson).

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