 |
|
Low Serum Calcium and High Parathyroid Hormone Levels in Neonates Fed 'Humanized' Cow's Milk—Based Formula
Bonny L. Specker, PhD;
Reginald C. Tsang, MBBS;
Mona L. Ho, MS;
Theresa M. Landi, MSN;
Teresa L. Gratton, MS
Am J Dis Child. 1991;145(8):941-945.
Abstract
• We previously suggested that "late" neonatal hypocalcemia is related to a low calcium-phosphorus ratio of current cow's milk—based formula compared with human milk. However, there are no longitudinal studies of ionized calcium and parathyroid hormone concentrations in neonates receiving formulas with varying Ca/P ratios. Sixty-nine term neonates were studied through 2 weeks of age, and formula-fed neonates were randomized at birth to receive formula with molar ratios of 0.9,1.2, or 1.4. Serum phosphate concentrations on days 2 and 6 of age were higher, and ionized calcium levels lower on days 6 and 14, in formula-fed vs human milk—fed neonates. Serum intact parathyroid hormone level increased between days 2 and 6 in formula-fed neonates compared with a decrease in human milk—fed neonates. Serum parathyroid hormone level on day 6 correlated with phosphorus intake among formula-fed neonates. No differences were noted in serum mineral or hormone levels among formula-fed groups. We speculate that the lowering of serum ionized calcium concentrations in neonates fed a modern "humanized" cow's milk formula may be a factor in late neonatal hypocalcemia.
(AJDC. 1991;145:941-945)
Author Affiliations
From the Division of Neonatology, Department of Pediatrics, University of Cincinnati (Ohio) Medical Center, Cincinnati Children's Hospital Medical Center, and Perinatal Research Institute, Cincinnati.
Footnotes
Accepted for publication April 18, 1991.
Presented in part at the Society for Pediatric Research Annual Meeting, Washington, DC, May 5, 1988.
Reprint requests to Department of Pediatrics, ML 541, University of Cincinnati Medical Center, Cincinnati, OH 45267-0541 (Dr Specker).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Nutrition Influences Bone Development from Infancy through Toddler Years
Specker
J. Nutr. 2004;134:691S-695.
ABSTRACT
| FULL TEXT
Maternal-Fetal Calcium and Bone Metabolism During Pregnancy, Puerperium, and Lactation
Kovacs and Kronenberg
Endocr Rev 1997;18:832-872.
ABSTRACT
| FULL TEXT
Randomized Trial of Varying Mineral Intake on Total Body Bone Mineral Accretion During the First Year of Life
Specker et al.
Pediatrics 1997;99:e12-e12.
ABSTRACT
| FULL TEXT
A Fresh Look at the Risks of Artificial Infant Feeding
Walker
J Hum Lact 1993;9:97-107.
ABSTRACT
|
