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Rodrigo Dominguez, MD; Antonio Aguirre Vila-Coro, MD; John M. Slopis, MD; Timothy P. Bohan, MD, PhD

Am J Dis Child. 1991;145(6):688-695.

Abstract
• We describe 10 infants with developmental delay and congenital cerebral anomalies who were found to have had in utero exposure to vasoactive drugs. Nine infants had ophthalmological abnormalities; these included strabismus, nystagmus, and/or hypoplastic optic discs. Six mothers used cocaine, one used cocaine and heroin, one used only heroin, one used amphetamine, and one used phenylpropanolamine. Each of these cerebral anomalies (agenesis of the corpus callosum, septo-optic dysplasia, schizencephaly, hydranencephaly, congenital hydrocephalus, porencephaly, and cerebral infarctions) can be attributed to insults at different stages of development. There appears to be a relationship between the time of prenatal drug exposure and the type of cerebral anomaly, evoking malformations, disruptions, or fetal strokes. Since many or possibly all of these anomalies are thought to have a vascular origin, it seems appropriate to implicate prenatal exposure to vasoactive drugs.

(AJDC. 1991;145:688-695)

Author Affiliations
From the Departments of Radiology (Dr Dominguez), Pediatrics (Drs Dominguez, Slopis, and Bohan), Ophthalmology (Dr Aguirre Vila-Coro), Neurology (Drs Slopis and Bohan), and Pharmacology (Dr Bohan), University of Texas Health Science Center, and the Mann Eye Clinic (Dr Aguirre Vila-Coro), Houston.

Footnotes
Accepted for publication January 4, 1991.

Reprint requests to Department of Radiology, University of Texas Health Science Center, 6431 Fannin, Room 2.132 MSB, Houston, TX 77030 (Dr Dominguez).

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