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The Causes of Hospital-Treated Acute Lower Respiratory Tract Infection in Children
Hanna Nohynek, MD;
Juhani Eskola, MD;
Eija Laine, MD;
Pekka Halonen, MD;
Petri Ruutu, MD;
Pekka Saikku, MD;
Marjaana Kleemola, MD;
Maija Leinonen, PhD
Am J Dis Child. 1991;145(6):618-622.
Abstract
• Objective
To determine the etiologic agents in children with acute lower respiratory infection.
Design
A survey of a series of patients.
Setting
General pediatric hospital serving an urban population with and without referrals in Helsinki, Finland. Participants: 135 Finnish children aged 2 months to 15 years (mean, 1.75 years), with clinically defined acute lower respiratory infection (with difficulty of breathing), or found to ave fever and a pneumonic infiltrate on chest roentgenogram.
Selection Procedures
Consecutive sample on voluntary basis.
Interventions
None.
Main Results
Of 121 children with adequate samples, an etiologic diagnosis could be established in 84 (70%): 30 (25%) had bacterial, 30 (25%) viral, and 24 (20%) mixed infections. Antibody assays alone identified the agent in 91% of positive cases.
Conclusions
Bacterial infections are common but generally underestimated in acute lower respiratory infection; serologic methods add significantly to their detection.
(AJDC. 1991;145:618-622)
Author Affiliations
From the National Public Health Institute, Helsinki, Finland (Drs Nohynek, Eskola, Kleemola, and Leinonen); Aurora Hospital, Helsinki (Drs Eskola and Laine); Second Department of Medicine, Helsinki University Central Hospital (Dr Ruutu); and the Departments of Virology, Universities of Helsinki (Dr Saikku) and Turku (Finland) (Dr Halonen).
Footnotes
Accepted for publication July 2, 1990.
Reprint requests to National Public Health Institute, Mannerheimintie 166, SF-00300 Helsinki, Finland (Dr Eskola).
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