The causes of hospital-treated acute lower respiratory tract infection in children
H. Nohynek, J. Eskola, E. Laine, P. Halonen, P. Ruutu, P. Saikku, M. Kleemola and M. Leinonen
National Public Health Institute, Helsinki, Finland.
OBJECTIVE: To determine the etiologic agents in children with acute lower
respiratory infection. DESIGN: A survey of a series of patients. SETTING:
General pediatric hospital serving an urban population with and without
referrals in Helsinki, Finland. PARTICIPANTS: 135 Finnish children aged 2
months to 15 years (mean, 1.75 years), with clinically defined acute lower
respiratory infection (with difficulty of breathing), or found to have
fever and a pneumonic infiltrate on chest roentgenogram. SELECTION
PROCEDURES: Consecutive sample on voluntary basis. INTERVENTIONS: None.
MAIN RESULTS: Of 121 children with adequate samples, an etiologic diagnosis
could be established in 84 (70%): 30 (25%) had bacterial, 30 (25%) viral,
and 24 (20%) mixed infections. Antibody assays alone identified the agent
in 91% of positive cases. CONCLUSIONS: Bacterial infections are common but
generally underestimated in acute lower respiratory infection; serologic
methods add significantly to their detection.
Effects of RSV infection on pulmonary surfactant protein SP-A in cultured human type II cells: contrasting consequences on SP-A mRNA and protein
Alcorn et al.
Am. J. Physiol. Lung Cell. Mol. Physiol. 2005;289:L1113-L1122.
ABSTRACT
| FULL TEXT
Burden of influenza in healthy children and their households
Principi et al.
Arch. Dis. Child. 2004;89:1002-1007.
ABSTRACT
| FULL TEXT
Comparison of Moraxella catarrhalis isolates from children and adults for growth on modified New York City medium and potential virulence factors
El Ahmer et al.
J Med Microbiol 2003;52:853-859.
ABSTRACT
| FULL TEXT
Parainfluenza Viruses
Henrickson
Clin. Microbiol. Rev. 2003;16:242-264.
ABSTRACT
| FULL TEXT
Community-Acquired Pneumonia in Children
McIntosh
NEJM 2002;346:429-437.
FULL TEXT
Quantitative Detection of Streptococcus pneumoniae in Nasopharyngeal Secretions by Real-Time PCR
Greiner et al.
J. Clin. Microbiol. 2001;39:3129-3134.
ABSTRACT
| FULL TEXT
Community acquired pneumonia---a prospective UK study
Drummond et al.
Arch. Dis. Child. 2000;83:408-412.
ABSTRACT
| FULL TEXT
Streptococcus pneumoniae and Mycoplasma pneumoniae coinfection in community acquired pneumonia
Toikka et al.
Arch. Dis. Child. 2000;83:413-414.
ABSTRACT
| FULL TEXT
Influenza and the Rates of Hospitalization for Respiratory Disease among Infants and Young Children
Izurieta et al.
NEJM 2000;342:232-239.
ABSTRACT
| FULL TEXT
Case 23-1999- A 10-Month-Old Girl with Fever, Upper-Lobe Pneumonia, and a Pleural Effusion
Husson and Mark
NEJM 1999;341:353-360.
FULL TEXT
Prospective Study To Determine Clinical Relevance of Detection of Pneumococcal DNA in Sera of Children by PCR
Dagan et al.
J. Clin. Microbiol. 1998;36:669-673.
ABSTRACT
| FULL TEXT