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Esophageal Motility in Children With Hirschsprung's Disease
Annamaria Staiano, MD;
Enrico Corazziari, MD;
Maria Rosaria Andreotti, MD;
Ray E. Clouse, MD
Am J Dis Child. 1991;145(3):310-313.
Abstract
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Esophageal motility was studied in 12 children with Hirschsprung's disease to see if extracolonic motor dysfunction was present in this disorder. Manometric tracings were compared with those from eight children with idiopathic megacolon and from 10 children without esophageal disease or constipation. Amplitude of esophageal contraction waves was significantly higher in children with Hirschsprung's disease than in the other two groups. Swallows that were followed by simultaneous contractions or double-peaked waves were also more common in the group with Hirschsprung's disease (subjects with Hirschsprung's disease, subjects with megacolon, and controls: 57%, 10%, and 8%, respectively). Lower esophageal sphincter characteristics did not differ among the three groups. The increase in simultaneous contractions and double-peaked waves persisted in those children who were reexamined following surgery for Hirschsprung's disease, whereas wave amplitudes fell to a level similar to that observed in the other groups. These data suggest that gastrointestinal motor dysfunction in persons with Hirschsprung's disease is not restricted to the colon, and that some of the observed abnormalities in esophageal motility do not reflect nonspecific responses to megacolon or colonic obstruction.
(AJDC. 1991;145:310-313)
Author Affiliations
From the Department of Pediatrics, II School of Medicine, University of Naples (Italy) (Drs Staiano and Andreotti), the Division of Gastroenterology I, Second Medical Clinic, La Sapienza University, Rome, Italy (Dr Corazziari), and the Division of Gastroenterology, Washington University School of Medicine, St Louis, Mo (Dr Clouse).
Footnotes
Accepted for publication August 13, 1990.
Presented at the 21st Annual Meeting of the European Society for Paediatric Gastroenterology and Nutrition, Budapest, Hungary, June 1, 1989.
Reprint requests to Dipartimento di Pediatria, II Facolta' di Medicina e Chirurgia, Via S Pansini, 5, 800131 Naples, Italy (Dr Staiano).
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
ESOPHAGEAL DYSFUNCTION IN HIRSCHSPRUNG'S DISEASE
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