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Lipoprotein Profiles in Hypercholesterolemic Children
Richard E. Garcia, MD;
Douglas S. Moodie, MD
Am J Dis Child. 1991;145(2):147-150.
Abstract
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• Atherosclerosis is a process that begins in early life. Coronary heart disease is the result of complex interactions among a variety of risk factors of which hypercholesterolemia is but one. During routine screening, 500 children were identified with total cholesterol levels above the 95th percentile of 5.2 mmol/L (200 mg/dL). Lipoprotein profiles were then performed to confirm and delineate their lipid abnormalities. A definable lipid disorder was present in 85% of such children. Abnormal lipoprotein patterns included 292 children with type IIa, 99 with type IIb, and 25 with type IV phenotypes. An abnormally low high-density lipoprotein cholesterol level of less than 0.9 mmol/L (35 mg/dL) was observed in 20 children. Only 5% of patients were identified as being hypercholesterolemic because they had high-density lipoprotein cholesterol levels above the 95th percentile of 1.8 mmol/L (70 mg/dL). Thirty-two percent of children with total cholesterol levels above 5.2 mmol/L had a family member (sibling, parent, uncle, aunt, or grandparent) with a myocardial infarction prior to 55 years of age. Data from this study support universal cholesterol testing after 3 years of age and lipoprotein profiles for those with levels above 5.2 mmol/L.
(AJDC. 1991;145:147–150)
Author Affiliations
From the Department of Pediatrics, Cleveland (Ohio) Clinic Foundation.
Footnotes
Accepted for publication October 1, 1990.
Reprint requests to Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Ave, Cleveland, OH 44195-5223 (Dr Garcia).
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