This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Philippe Lepage, MD; Philippe Van de Perre, MD; Guy Van Vliet, MD, PhD; François Nsengumuremyi, MD; Christiaan Van Goethem, MD; Philippe Kestelyn, MD; Philippe Msellati, MD; Deo-Gratias Hitimana, MD

Am J Dis Child. 1991;145(11):1248-1251.

Abstract
• Sixteen human immunodeficiency virus type 1 (HIV-1 )—seropositive children aged 5 to 12 years (nine girls and seven boys), born to HIV-1—infected mothers, were diagnosed between 1984 and 1987 in Kigali, Rwanda. They were compared with a group of age- and sex-matched HIV-1—sero-negative children consecutively selected from the outpatient department. Two subjects were asymptomatic. Chronic cough was the most frequent symptom (seven of 16 patients). The most common signs were short stature (12 of 16 patients), low weight for age (seven of 16 patients), chronic parotitis (eight of 16 patients), persistent generalized lymphadenopathy (seven of 16 patients), and pulmonary tuberculosis (four of 16 patients). Lymphoid interstitial pneumonitis was diagnosed on radiologic grounds in five of 16 patients. Evidence of perivasculitis in the fundus was noted in three of 16 patients. Two children died during the study period (mean duration of follow-up, 40 months; range, 27 to 62 months); none of the other children had life-threatening infection or loss of developmental milestones. Immunologic assessment in the 16 children revealed high levels of IgG, decreased CD4 ⁺/CD8⁺ ratio, and skin test anergy. Endocrinologic investigations revealed normal thyroid function and normal basal human growth hormone levels but low basal insulinlike growth factor I levels (0.21±0.07 vs 0.44±0.20 U/mL for controls). In Kigali, perinatally HIV-1—infected children surviving beyond 5 years of age often present with moderate signs and symptoms, principally pulmonary involvement, chronic parotitis, and persistent generalized lymphadenopathy. Short stature is the major clinical manifestation in these patients and may be due, in part, to low growth hormone secretion rather than to malnutrition.

(AJDC. 1991;145:1248-1251)

Author Affiliations
From the Departments of Pediatrics (Drs Lepage, Nsengumuremyi, Van Goethem, and Hitimana) and Ophthalmology (Dr kestelyn), Centre Hospitalier de Kigali (Rwanda); the National Reference Laboratory, AIDS Control Program, Kigali (Dr Van de Perre); the Department of Pediatrics, Université Libre de Bruxelles (Belgium) (Dr Van Vliet); and INSERM, Unité 330, Bordeaux, France (Dr Msellati). Dr Van Vliet is now with the Research Center and Endocrine Service, Department of Pediatrics, Hôpital St Justine, Université de Montréal, Québec.

Footnotes
Accepted for publication April 22, 1991.

Reprint requests to 12, Eve Taille Cuvelier, 7000 Nous, Belgium (Dr Lepage).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Morbidity in HIV-1-Infected Children Treated or Not Treated with Highly Active Antiretroviral Therapy (HAART), Abidjan, Cote d'Ivoire, 2000-04
Walenda et al.
J Trop Pediatr 2009;55:170-176.
ABSTRACT | FULL TEXT  

Morbidity Among Human Immunodeficiency Virus-1-Infected and -Uninfected African Children
Taha et al.
Pediatrics 2000;106:77e-77.
ABSTRACT | FULL TEXT  

Natural History of Human Immunodefiency Virus Type 1 Infection in Children: A Five-Year Prospective Study in Rwanda
Spira et al.
Pediatrics 1999;104:56e-56.
ABSTRACT | FULL TEXT  

Insulin-Like Growth Factor-I Resistance
Jain et al.
Endocr. Rev. 1998;19:625-646.
ABSTRACT | FULL TEXT  

HIV gp120 inhibits the somatotropic axis: A possible GH-releasing hormone receptor mechanism for the pathogenesis of AIDS wasting
Mulroney et al.
Proc. Natl. Acad. Sci. USA 1998;95:1927-1932.
ABSTRACT | FULL TEXT