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How Much Vitamin D for Neonates?
William B. Pittard III, MD;
Kitty M. Geddes, RN, BSN;
Thomas C Hulsey, MSPH, ScD;
Bruce W. Hollis, PhD
Am J Dis Child. 1991;145(10):1147-1149.
Abstract
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To assess the adequacy of different dosages of neonatal vitamin D, 25–hydroxyvitamin D serum concentrations were longitudinally monitored in 27 low-birth-weight and 25 full-term well infants from birth to 16 weeks after delivery. The infants were randomly assigned to receive either 10 µg/d (400 IU/d) or 20 µg/d (800 IU/d) of vitamin D or 0.85 or 1.5 µg/d of 25–hydroxyvitamin D3. In each infant who received 10 or 20 µg/d of vitamin D 25–hydroxyvitamin D, serum concentrations greater than 20 ng/mL were maintained, with some low-birth-weight infants reaching 60-ng/mL concentrations. Similarly, in the low-birth-weight infants receiving 1.5 and 0.85 µg/d of 25–hydroxyvitamin D3, serum 25–hydroxyvitamin Dlevels greater than 12 ng/mL were maintained. In the full-term infants who received 1.5 µg/d of 25–hydroxyvitamin D3, serum 25–hydroxyvitamin D concentrations of greater than 12 ng/mL were maintained, but in those who received 0.85 µg/d, serum 25–hydroxyvitamin D concentrations of 10 ng/mL could not be maintained. These vitamin D status data document that 10 µg (400IU) of vitamin D represents a sufficient daily intake for both premature and full-term well infants. These data also indicate that while as little as 0.85 µg/d of 25–hydroxyvitamin D3 may facilitate vitamin D sufficiency in low-birth-weight neonates, it does not do so in full-term infants.
(AJDC. 1991;145:1147-1149)
Author Affiliations
From the Department of Pediatrics, Medical University of South Carolina, Charleston.
Footnotes
Accepted for publication February 11, 1991.
Reprint requests to the Department of Pediatrics, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425-3313 (Dr Pittard).
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