This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

William B. Pittard III, MD; Kitty M. Geddes, RN, BSN; Thomas C Hulsey, MSPH, ScD; Bruce W. Hollis, PhD

Am J Dis Child. 1991;145(10):1147-1149.

Abstract
• To assess the adequacy of different dosages of neonatal vitamin D, 25–hydroxyvitamin D serum concentrations were longitudinally monitored in 27 low-birth-weight and 25 full-term well infants from birth to 16 weeks after delivery. The infants were randomly assigned to receive either 10 µg/d (400 IU/d) or 20 µg/d (800 IU/d) of vitamin D or 0.85 or 1.5 µg/d of 25–hydroxyvitamin D₃. In each infant who received 10 or 20 µg/d of vitamin D 25–hydroxyvitamin D, serum concentrations greater than 20 ng/mL were maintained, with some low-birth-weight infants reaching 60-ng/mL concentrations. Similarly, in the low-birth-weight infants receiving 1.5 and 0.85 µg/d of 25–hydroxyvitamin D₃, serum 25–hydroxyvitamin Dlevels greater than 12 ng/mL were maintained. In the full-term infants who received 1.5 µg/d of 25–hydroxyvitamin D₃, serum 25–hydroxyvitamin D concentrations of greater than 12 ng/mL were maintained, but in those who received 0.85 µg/d, serum 25–hydroxyvitamin D concentrations of 10 ng/mL could not be maintained. These vitamin D status data document that 10 µg (400IU) of vitamin D represents a sufficient daily intake for both premature and full-term well infants. These data also indicate that while as little as 0.85 µg/d of 25–hydroxyvitamin D₃ may facilitate vitamin D sufficiency in low-birth-weight neonates, it does not do so in full-term infants.

(AJDC. 1991;145:1147-1149)

Author Affiliations
From the Department of Pediatrics, Medical University of South Carolina, Charleston.

Footnotes
Accepted for publication February 11, 1991.

Reprint requests to the Department of Pediatrics, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425-3313 (Dr Pittard).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Vitamin D Supplementation during Lactation to Support Infant and Mother
Taylor et al.
J. Am. Coll. Nutr. 2008;27:690-701.
ABSTRACT | FULL TEXT  

Circulating 25-Hydroxyvitamin D Levels Indicative of Vitamin D Sufficiency: Implications for Establishing a New Effective Dietary Intake Recommendation for Vitamin D
Hollis
J. Nutr. 2005;135:317-322.
ABSTRACT | FULL TEXT  

Assessment of dietary vitamin D requirements during pregnancy and lactation
Hollis and Wagner
Am. J. Clin. Nutr. 2004;79:717-726.
ABSTRACT | FULL TEXT  

Maturation of primary and permanent teeth in preterm infants
Backström et al.
Arch. Dis. Child. Fetal Neonatal Ed. 2000;83:104F-108.
ABSTRACT | FULL TEXT  

Randomised controlled trial of vitamin D supplementation on bone density and biochemical indices in preterm infants
Backström et al.
Arch. Dis. Child. Fetal Neonatal Ed. 1999;80:161F-166.
ABSTRACT | FULL TEXT