 |
|
Invasive Disease due to Multiply Resistant Streptococcus pneumoniae in a Houston, Tex, Day-care Center
Alan M. Rauch, MD;
Miguel O'Ryan, MD;
Rory Van, MS;
Larry K. Pickering, MD
Am J Dis Child. 1990;144(8):923-927.
Abstract
• Two toddlers who attended the same day-care center were hospitalized hours apart with sepsis and meningitis due to a multiply resistant Streptococcus pneumoniae. We determined the prevalence of multiply resistant S pneumoniae respiratory carriage and disease in infants, toddlers, and staff in the day-care center and in household contacts. The nasopharynges of 82 (96%) of 85 day-care center children, 26 (90%) of 29 day-care center staff, and 28 (90%) of 31 family members were cultured. Streptococcus pneumoniae grew from 29 (35%) of the 82 cultured day-care center children. Ten (34%) of the S pneumoniae isolates were resistant to sulfamethoxazole-trimethoprim, oxacillin, and tetracycline and were relatively resistant to penicillin (minimum inhibitory concentration, 0.5 mg/L). All were serotype 14 and had the same antibiotic resistance pattern. Treatment of 97% of the day-care center children and staff with rifampin (10 mg/kg twice daily for 2 days) resulted in 70% reduction in positive nasopharyngeal cultures for S pneumoniae. No additional disease due to multiply resistant S pneumoniae was identified in the day-care center during a 9-month followup period. This report documents that an outbreak of multiply resistant invasive S pneumoniae occurred in a day-care center setting; that nasopharyngeal colonization of exposed children was common; and that rifampin treatment of 2 days only partially eradicated the organism from colonized individuals.
(AJDC. 1990;144:923-927)
Author Affiliations
From the Division of Infectious Diseases, Department of Pediatrics, University of Texas Medical School at Houston. Dr Rauch is now with Merck Sharp & Dohme, Bluebell, Pa.
Footnotes
Accepted for publication November 27, 1989.
Reprint requests to Pediatric Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin St, Room 1.739, Houston, TX 77030 (Dr Pickering).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Outbreak of Streptococcus pneumoniae serotype 1 pneumonia in a United Kingdom school
Gupta et al.
BMJ 2008;337:a2964-a2964.
FULL TEXT
Modeling the Association between Pneumococcal Carriage and Child-Care Center Attendance
Dagan and O'Brien
Clinical Infectious Diseases 2005;40:1223-1226.
FULL TEXT
Reduction of Nasopharyngeal Carriage of Streptococcus pneumoniae after Administration of a 9-Valent Pneumococcal Conjugate Vaccine to Toddlers Attending Day Care Centers
Dagan et al.
The Journal of Infectious Disease 2002;185:927-936.
ABSTRACT
| FULL TEXT
Antibiotic-Resistant Pneumococci Carried by Young Children Do Not Appear to Disseminate to Adult Members of a Closed Community
Borer et al.
Clinical Infectious Diseases 2001;33:436-444.
ABSTRACT
| FULL TEXT
Measuring and Interpreting Associations between Antibiotic Use and Penicillin Resistance in Streptococcus pneumoniae
Lipsitch
Clinical Infectious Diseases 2001;32:1044-1054.
ABSTRACT
| FULL TEXT
Technical Report: Prevention of Pneumococcal Infections, Including the Use of Pneumococcal Conjugate and Polysaccharide Vaccines and Antibiotic Prophylaxis
Overturf et al.
Pediatrics 2000;106:367-376.
ABSTRACT
| FULL TEXT
Carriage of Multidrug-Resistant Streptococcus pneumoniae and Impact of Chemoprophylaxis During an Outbreak of Meningitis at a Day Care Center
Craig et al.
Clinical Infectious Diseases 1999;29:1257-1264.
ABSTRACT
| FULL TEXT
Editorial Response: Multidrug-Resistant Streptococcus pneumoniae: An Opportunity to Further Understand Pneumococcal Ecology and to Better Predict Intervention Outcomes
Leach
Clinical Infectious Diseases 1999;29:1265-1267.
FULL TEXT
AN OUTBREAK OF MULTIPLY-RESISTANT PNEUMOCOCCI
JWatch General 1990;1990:3-3.
FULL TEXT
|
