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The Effect of 100% Oxygen on the Propagation of Tracheobronchial Injury During High-Frequency and Conventional Mechanical Ventilation
LTC Thomas E. Wiswell, MD, MC;
CPT Susan H. Wiswell
Am J Dis Child. 1990;144(5):560-564.
Abstract
• We compared the histologic alterations in the tracheae and bronchi of 30 premature baboons that were ventilated with either 100% or prn (as needed) oxygen (the fraction of inspired oxygen necessary to maintain the PaO2 between 50 and 80 mm Hg). The baboons were treated with either conventional positive-pressure ventilation (7 were treated with 100%; 7, prn) or high-frequency oscillatory ventilation (8 were treated with 100%; 8, prn). We used a semiquantitative scoring system to grade tissue changes in the trachea, carina, and main-stem bronchi. The fraction of inspired oxygen for all prn animals fell to a plateau of approximately 0.28 after 36 hours, where it remained for the duration of the study. The 15 100% baboons were ventilated for a mean of 139 hours, while the 15 prn baboons were ventilated for a mean of 151 hours. The findings in all conventional and oscillator-ventilated animals were similar and characterized by squamous metaplasia, cilia loss, and goblet cell loss. For both methods of ventilation, there were no differences in the injury scores between 100% and prn oxygen-treated animals. We concluded that there were no additional tracheobronchial histologic changes with 100% oxygen compared with prn oxygen.
(AJDC. 1990;144:560-564)
Author Affiliations
From the Department of the Army, Walter Reed Army Medical Center, Washington, DC.
Footnotes
Accepted for publication November 28, 1989.
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, the Department of Defense, the Southwest Foundation for Biomedical Research, or the University of Texas at San Antonio.
Reprint requests to Department of Pediatrics, Walter Reed Army Medical Center, Washington, DC 20307-5001 (Dr Wiswell).
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