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Anatomic Types and Associated Malformations

Bruno Marino, MD; Marco Papa, MD; Paolo Guccione, MD; Antonio Corno, MD; Maurizio Marasini, MD; Raffaele Calabró, MD

Am J Dis Child. 1990;144(5):544-545.

Abstract
• Ventricular septal defect is a common cardiac anomaly in Down syndrome. To detect the prevalence of anatomic types and associated cardiac malformations we analyzed the echocardiographic and angiocardiographic findings of 73 children with ventricular septal defect and Down syndrome. We compared these results with those obtained in 303 patients with ventricular septal defect without Down syndrome. The prevalence of inlet ventricular septal defect was significantly higher in patients with Down syndrome, while muscular and subpulmonary ventricular septal defects were present only in patients without Down syndrome. The incidence of a cleft of the mitral valve was significantly higher in Down syndrome, while left-ventricular inflow and outflow obstructions were present only in patients without Down syndrome. Different patterns of ventricular septal defect and associated anomalies exist in patients with and without Down syndrome.

(AJDC. 1990;144:544-545)

Author Affiliations
From the Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesú Hospital, Rome, Italy (Drs Marino, Papa, Guccione, and Corno); the Division of Cardiology, Gaslini Hospital, Genoa, Italy (Dr Marasini); and the Division of Pediatric Cardiology, Monaldi Hospital, Naples, Italy (Dr Calabró).

Footnotes
Accepted for publication August 23, 1989.

Reprint requests to Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesú Hospital, Piazza Sant'Onofrio 4,00165 Rome, Italy (Dr Marino).

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