This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

The First 10 Years

John H. Githens, MD; Peter A. Lane, MD; Robert S. McCurdy, MD, MPH; Marva L. Houston, RN; James D. McKinna, MS; Doris M. Cole, RN

Am J Dis Child. 1990;144(4):466-470.

Abstract
• In Colorado, newborn screening for hemoglobinopathies by cellulose acetate and citrate agar electrophoresis of dried capillary blood spots was established in 1979. We reviewed the results of screening 528 711 infants through 1988. Forty-seven infants with sickle cell diseases and 27 infants with other hemoglobin diseases were identified. The initial screening failed to detect sickle cell anemia in 4 infants, but the hemoglobinopathy in 3 of these infants was diagnosed correctly by routine retesting of those with suspected sickle cell trait. A total of 47 infants with sickle cell diseases were followed through September 1989. There was no mortality among these infants. The screening test identified 3779 infants (1:140 births) with a suspected hemoglobin trait; confirmatory retesting was obtained in 53%. The results of our experience confirm the value of newborn screening for hemoglobinopathies but suggest that a more sensitive test would improve the program.

(AJDC. 1990;144:466-470)

Author Affiliations
From the Department of Pediatrics and the Colorado Sickle Cell Treatment and Research Center, University of Colorado School of Medicine (Drs Githens and Lane and Mss Houston and Cole) and the Mountain States Newborn Screening Laboratory, Colorado Department of Health (Dr McCurdy and Mr McKinna), Denver.

Footnotes
Accepted for publication November 28, 1989.

Reprint requests to Box C-222, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262 (Dr Lane).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effect of a comprehensive clinical care program on disease course in severely ill children with sickle cell anemia in a sub-Saharan African setting
Rahimy et al.
Blood 2003;102:834-838.
ABSTRACT | FULL TEXT  

Costing model for neonatal screening and diagnosis of haemoglobinopathies
Cronin et al.
Arch. Dis. Child. Fetal Neonatal Ed. 1998;79:161F-167.
ABSTRACT | FULL TEXT  

Fortnightly Review: Neonatal screening for sickle cell disorders: what about the carrier infants?
Laird et al.
BMJ 1996;313:407-411.
ABSTRACT | FULL TEXT