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Outcome at 5 to 6 Years of Age

Jean Lowe, PhD; LuAnn Papile, MD

Am J Dis Child. 1990;144(11):1242-1245.

Abstract
• The neurodevelopmental outcome of 38 very-low-birth-weight neonates (birth weight, <1501 g) was followed up prospectively from birth to 5 to 6 years of age to assess the neurodevelopmental sequelae of mild periventricular, intraventricular hemorrhage (grades I and II). All neonates were screened for periventricular, intraventricular hemorrhage at 5 to 10 days of age. Eleven incurred a mild periventricular, intraventricular hemorrhage (group 1) and 27 had no periventricular, intraventricular hemorrhage (group 2). Each of the infants was neurodevelopmentally normal at 1 to 2 years of age. The 38 children were matched by race, age, sex, and socioeconomic status with control children (group 3) who had been born at term. On outcome measurements at 5 to 6 years of age, groups 1 and 2 scored significantly lower than group 3 on the combined test measurements and on three of the four individual measurements. Group 1 scored significantly lower than group 2 on the combined test measurements only. These data indicate that very-low-birth-weight infants are at risk for learning problems. Although children with mild periventricular, intraventricular hemorrhage did not demonstrate a significant deficit on individual test scores, the significant difference on the combined battery suggests that mild periventricular, intraventricular hemorrhage has an adverse effect on global performance.

(AJDC. 1990;144:1242-1245)

Author Affiliations
From the Division of Neonatology, Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque.

Footnotes
Accepted for publication April 9, 1990.

Reprint requests to Department of Pediatrics, University of New Mexico Hospital, 4 North, Albuquerque, NM 87131 (Dr Papile).

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