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  Vol. 144 No. 10, October 1990 TABLE OF CONTENTS
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Atrioventricular Canal in Down Syndrome

Prevalence of Associated Cardiac Malformations Compared With Patients Without Down Syndrome

Bruno Marino, MD; Ugo Vairo, MD; Antonio Corno, MD; Simonetta Nava, MD; Paolo Guccione, MD; Raffaele Calabró, MD; Carlo Marcelletti, MD

Am J Dis Child. 1990;144(10):1120-1122.


Abstract

• The atrioventricular canal is the "classic" congenital heart anomaly in Down syndrome. We may learn more of the nature of this disorder by careful study of the anatomic characteristics of the cardiac lesions and by comparing these lesions in patients with and patients without Down syndrome. We reviewed the clinical characteristics (echocardiographic and angiocardiographic) of 220 patients with atrioventricular canal and compared the prevalence of anatomic types and associated cardiac malformations in children with (105) and without (115) Down syndrome. In patients with Down syndrome, the complete form of atrioventricular canal was prevalent, with a high frequency of associated Fallot's tetralogy. Partial atrioventricular canal and left-sided anomalies were more common in patients without Down syndrome. Down syndrome is associated with a simpler type of atrioventricular canal when compared with patients with a normal chromosome configuration.

(AJDC. 1990;144:1120-1122)



Author Affiliations

From the Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesu' Hospital and Research Institute, Rome (Drs Marino, Vairo, Corno, Nava, Guccione, and Marcelletti); and the Department of Pediatric Cardiology, Monaldi Hospital, Naples (Dr Calabró), Italy. Dr Corno is now with San Raffaele Hospital, Milan, Italy.


Footnotes

Accepted for publication April 9, 1990.

Reprint requests to Dipartimento Medico-Chirurgico di Cardiologia Pediatrica, Ospedale Bambino Gesu', Piazza Sant'Onofrio, 4 00165 Rome, Italy (Dr Marino).



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