This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Francis J. DiMario, Jr, MD; Robert Clancy, MD

Am J Dis Child. 1989;143(9):1056-1060.

Abstract
• We describe the clinical and radiographic features of three premature infants with symmetric thalamic calcification recognized by computed tomographic scan on days 6, 12, and 49 of life and contrast our findings with those reported in the literature. These lesions follow prepartum or intrapartum hypoxiaischemia and are clinically distinguished by prominent bulbar dysfunction, featuring weak or absent cry, poor feeding, and facial weakness. Neonatal thalamic calcification in premature infants may serve as a radiological marker of an acute, shortlived hypoxic-ischemic event. The presence of brain-stem dysfunction, particularly of lower cranial nerves in association with thalamic calcifications, constitutes a distinctive clinical-radiological entity and usually portends a poor outcome. The presence of these calcifications implies that injury was sustained to diencephalic and brain-stem structures at least 2 to 4 weeks prior to their appearance on computed tomographic scan.

(AJDC. 1989;143:1056-1960)

Author Affiliations
From the Division of Pediatric Neurology, Department of Pediatrics and Neurology, the University of Connecticut Health Center, University of Connecticut School of Medicine, Farmington (Dr DiMario), and the Division of Neurology, the Children's Hospital of Philadelphia (Pa), and the Department of Neurology and Pediatrics, the University of Pennsylvania School of Medicine, Philadelphia (Dr Clancy).

Footnotes
Accepted for publication May 31, 1989.

Reprint requests to Division of Pediatric Neurology, Department of Pediatrics, University of Connecticut Health Center, Farmington Avenue, Farmington, CT 06032 (Dr DiMario).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

From Fossil to Fetus: Nonhemorrhagic Germinal Matrix Echodensity Caused by Mineralizing Vasculitis--Hypothesis of Fossilizing Germinolysis and Gliosis
van Baalen and Rohr
J Child Neurol 2009;24:36-44.
ABSTRACT