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Aubert Lavoie, MD; Menachem Rottem, MD; Marshall P. Grodofsky, MD; Steven D. Douglas, MD

Am J Dis Child. 1989;143(9):1038-1041.

Abstract
• Four infants with hyperimmunoglobulinemia E presented with a persistent papulovesicular rash and eosinophilia. Serum IgE levels and specific anti-Staphylococcus aureus IgE antibodies were studied during the first year of life. Increased anti-S aureus IgE antibodies were an early indicator of the disease; they appeared as soon as 7 weeks of age in patient 1 and before 1 year of age for the other patients. These antibodies were detected before the development of deeper staphylococcal infections. Prompt diagnosis and treatment are important, as they may prevent long-term infectious complications.

(AJDC. 1989;143:1038-1041)

Author Affiliations
From the Department of Pediatrics, Division of Allergy-Immunology-Bone Marrow Transplantation, Children's Hospital of Philadelphia, University of Pennsylvania Medical School. Dr Lavoie is now with Unité de recherche, Inflammation et Immunologie-Rhumatologie, Centre Hospitalier de l'Université Laval. Dr Grodofsky is nowwith Pediatric Allergy Associates, Hartford, Conn.

Footnotes
Accepted for publication May 2, 1989.

Reprints not available.

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