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Success and Relapse Rate

Giuseppe Saggese, MD; Paolo Ghirri, MD; Stefano Gabrielli, MD; Giulio C. M. Cosenza, MD

Am J Dis Child. 1989;143(8):980-982.

Abstract
• We treated 163 patients (Tanner stage I), aged 1 to 11 years, with cryptorchidism with a combination of 500 to 2000 IU of human chorionic gonadotropin divided into two intramuscular injections and given weekly and 75 IU of follicle-stimulating hormone once a week for 6 weeks. One hundred twelve patients had unilateral cryptorchidism. Response to therapy, which is descent of testes into scrotum, by age group was as follows: 2(13.3%) of 15 patients aged 1 to 2 years; 8 (29.6%) of 27 patients aged 3 to 4 years; 13(38.2%) of 34 patients aged 5 to 6 years; and 18 (50%) of 36 patients aged 7 to 11 years. Fifty-one patients had bilateral cryptorchidism. Response by age group was as follows: 1 (16.6%) of 6 patients aged 1 to 2 years; 3 (27.2%) of 11 patients aged 3 to 4 years; 6 (37.5%) of 16 (plus unilateral descent in 1 patient) aged 5 to 6 years; and 10 (55.5%) of 18 patients aged 7 to 11 years. The results are comparable with those obtained with human chorionic gonadotropin treatment alone. A relapse rate of 9.7% after 18 months of follow-up seemed to be lower compared with those reported with treatment with gonadatropin-releasing hormone or treatment with human chorionic gonadotropin alone.

(AJDC. 1989;143:980-982)

Author Affiliations
From the Department of Pediatrics, University of Pisa, Italy.

Footnotes
Accepted for publication February 27, 1989.

Reprint requests to Department of Pediatrics, University of Pisa, Via Roma 35, 56100 Pisa, Italy (Dr Saggese).

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