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Risk of Infectious Complications in Well-Appearing Children With Transient Neutropenia
Anthony J. Alario, MD;
John S. O'Shea, MD
Am J Dis Child. 1989;143(8):973-976.
Abstract
• To determine whether well-appearing children found incidentally to be neutropenic are at risk for an infectious complication, 44 consecutive months of hematology laboratory records were reviewed. One hundred nineteen patients had medical record documentation regarding clinical course, serial white blood cell counts, and the absence of serious infections, chronic illnesses, or a family history known to be associated with neutropenia. The median duration of documented neutropenia was 13 days (range, 1 to 491 days). Infectious complications occurred in 4 of the 36 patients who had neutropenia for more than 30 days (2 with stomatitis, 1 with cellulitis, and 1 with pneumonia) but in none with shorter durations of neutropenia. There were no significant associations between the development of an infectious complication and either the initial absolute neutrophil count or the lowest documented absolute neutrophil count, nor was there a correlation between the initial absolute neutrophil count and the duration of neutropenia. These data indicate that infectious complications occur in otherwise well children with unexplained neutropenia that persists, but these infections are infrequent and usually are superficial.
(AJDC. 1989;143:973-976)
Author Affiliations
From the Division of Ambulatory Pediatrics, Department of Pediatrics, Rhode Island Hospital and Brown University, Providence.
Footnotes
Accepted for publication March 3, 1989.
Read in part at the 57th Annual Meeting of the Society for Pediatric Research, Washington, DC, May 5, 1988.
Reprint requests to Division of Ambulatory Pediatrics, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903 (Dr Alario).
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
RISK OF INFECTION IN NEUTROPENIC CHILDREN
JWatch General 1989;1989:7-7.
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