 |
 |

Prenatal Cocaine Exposure Is Associated With Respiratory Pattern Abnormalities
Ira J. Chasnoff, MD;
Carl E. Hunt, MD;
Ron Kletter, PhD;
David Kaplan, MD
Am J Dis Child. 1989;143(5):583-587.
Abstract
 |  |
As retrospectively determined, the rate of sudden infant death syndrome in 66 infants prenatally exposed to cocaine was 15%, compared with only 4% among infants exposed to opiates. This prospective evaluation of cardiorespiratory pattern in 32 cocaine-exposed and 18 methadone-exposed infants was therefore performed to further evaluate the effects of intrauterine exposure. The two groups were similar in maternal age, race, and cigarette, alcohol, and marijuana use and in gestational age, sex, and birth weight. Apnea density and episodes of periodic breathing exceeded the 95th percentile for normal infants in 12 (38%) of 32 of cocaine-exposed infants vs only 1 (6%) of 18 opiate-exposed infants. Five cocaine-exposed but no opiate-exposed infants had apnea of infancy, and all 5 of these infants had an abnormal cardiorespiratory pattern. In all 13 infants with an abnormal cardiorespiratory pattern, theophylline treatment resulted in normalization of the respiratory pattern and was associated with absence of any (further) clinical events. In summary, infants prenatally exposed to cocaine have a higher incidence of cardiorespiratory pattern abnormalities than do infants with methadone or no prenatal drug exposure.
(AJDC. 1989;143:583-587)
Author Affiliations
From the Departments of Pediatrics (Drs Chasnoff and Hunt) and Psychiatry (Drs Chasnoff, Kletter, and Kaplan), Northwestern University Medical School, Chicago, Ill. Dr Hunt is now with the Department of Pediatrics, Medical College of Ohio, Toledo.
Footnotes
Accepted for publication February 13, 1989.
Presented in part to the Society for Pediatric Research, Washington, DC, May 8, 1986.
Reprint requests to Department of Pediatrics, Medical College of Ohio, PO Box 10008, Toledo, OH 43699-0008 (Dr Hunt).
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Perinatal Substance Abuse: The Impact of Reporting Infants to Child Protective Services
MacMahon
Pediatrics 1997;100:e1-e1.
ABSTRACT
| FULL TEXT
Detection of intrauterine illicit drug exposure by newborn drug testing
Kwong and Ryan
Clin. Chem. 1997;43:235-242.
ABSTRACT
| FULL TEXT
Ovine Fetal-Placental Cocaine Pharmacokinetics During Continuous Cocaine Infusion
Downs et al.
Reproductive Sciences 1996;3:185-190.
ABSTRACT
Neurologic and Ophthalmologic Findings in Children Exposed to Cocaine in Utero
Tsay et al.
J Child Neurol 1996;11:25-30.
ABSTRACT
Utility of Laboratory Screening in Cocaine-Exposed Infants
Beltran et al.
CLIN PEDIATR 1994;33:683-685.
Is There a Cocaine Baby Syndrome?
Konkol
J Child Neurol 1994;9:225-226.
|