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Gastrointestinal Milk Intolerance of Infancy
Stuart Berezin, MD;
Steven M. Schwarz, MD;
Mark Glassman, MD;
Marianna Davidian, MD;
Leonard J. Newman, MD
Am J Dis Child. 1989;143(3):361-362.
Abstract
• During a period of 30 months, cow's milk–or soy protein–induced colitis was diagnosed in 22 infants. All patients presented with hematochezia. Only three patients had substantial diarrhea. Colonoscopic evaluations demonstrated a characteristic mucosal appearance, manifested by aphthoid ulcerations with intervening, normal-appearing mucosa. Histologic findings included surface ulcerations and associated inflammation of the lamina propria and submucosa, marked by substantial eosinophilic infiltration. Both clinical symptoms and colonoscopic abnormalities rapidly resolved in all patients after the elimination of cow's milk and/or soy protein from the diet. These data indicate that hematochezia may be the predominant symptom of cow's milk protein and soy protein intolerance in many affected infants, and that colonoscopy is the most effective means of establishing a definitive diagnosis in this patient population.
(AJDC 1989;143:361-362)
Author Affiliations
From the Department of Pediatrics, Division of Gastroenterology and Nutrition (Drs Berezin, Schwarz, Glassman, Newman), and the Department of Pathology (Dr Davidian), New York Medical College, Valhalla.
Footnotes
Accepted for publication Nov 14, 1988.
Reprint requests to New York Medical College, Department of Pediatrics, Munger Pavilion, Valhalla, NY 10595 (Dr Berezin).
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