Failure of once-daily penicillin V therapy for streptococcal pharyngitis
M. A. Gerber, M. F. Randolph, K. DeMeo, H. M. Feder Jr and E. L. Kaplan
Department of Pediatrics, University of Connecticut School of Medicine, Farmington.
To determine if a single daily dose of penicillin V would be effective in
the treatment of group A beta-hemolytic streptococcal (GABHS) pharyngitis,
154 patients with GABHS pharyngitis were randomly assigned to receive 750
mg of penicillin V once daily for ten days or 250 mg of penicillin V three
times daily for ten days. The two regimens were comparable in their ability
to eradicate GABHS from the upper respiratory tract in 18 to 24 hours and
in their impact on the clinical course of the disease. However, a
bacteriologic treatment failure occurred in six (8%) of the 76 patients in
the three-times-daily group and in 16 (22%) of the 74 patients in the
once-daily group. These findings support the current recommendation that
penicillin V be given in two or more divided doses for a full ten days for
the treatment of GABHS pharyngitis.
Once-daily amoxicillin versus twice-daily penicillin V in group A {beta}-haemolytic streptococcal pharyngitis
Lennon et al.
Arch. Dis. Child. 2008;93:474-478.
ABSTRACT
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The Importance of Bacteriologic Eradication in the Treatment of Group A Streptococcal Tonsillopharyngitis
Pichichero
CLIN PEDIATR 2007;46:3S-16S.
ABSTRACT
Efficacy of Cephalexin Two vs. Three Times Daily vs. Cefadroxil Once Daily for Streptococcal Tonsillopharyngitis
Curtin et al.
CLIN PEDIATR 2003;42:519-526.
ABSTRACT
The Impact of Dosing Frequency on the Efficacy of 10-Day Penicillin or Amoxicillin Therapy for Streptococcal Tonsillopharyngitis: A Meta-analysis
Lan et al.
Pediatrics 2000;105:19e-19.
ABSTRACT
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Potential Mechanisms for Failure to Eradicate Group A Streptococci From the Pharynx
Gerber et al.
Pediatrics 1999;104:911-917.
ABSTRACT
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Once-Daily Therapy for Streptococcal Pharyngitis With Amoxicillin
Feder Jr et al.
Pediatrics 1999;103:47-51.
ABSTRACT
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Treatment of Common Respiratory Tract Infections
Paap and Nahata
Journal of Pharmacy Practice 1991;4:158-169.
SINGLE DAILY PENICILLIN NOT EFFECTIVE FOR STREP THROAT
JWatch General 1989;1989:5-5.
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