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Nestor E. Vain, MD; Luis M. Prudent, MD; Deborah P. Stevens, RRT; Margaret M. Weeter, RRT; M. Jeffrey Maisels, MB, BCh

Am J Dis Child. 1989;143(12):1458-1460.

Abstract
• The administration of oxygen to infants via nasal cannulas is now a common practice in neonatal units although the inspired oxygen concentration reaching the patient's airway is unknown. We measured the hypopharyngeal oxygen concentration in 10 infants who were receiving oxygen via nasal cannulas and assessed the impact of changes in the flow rate and inspired oxygen concentration. Weaning these infants by reducing the flow rate, even if changes are slight, produces clinically important changes in the oxygen concentration reaching the airway. Such changes are poorly tolerated by infants with chronic lung disease. Changing the flow rate and inspired oxygen concentration, rather than the flow rate alone, provides greater precision and is likely to avoid excessive and abrupt changes in the oxygen concentration reaching the airway.

(AJDC. 1989;143:1458-1460)

Author Affiliations
From the Division of Newborn Medicine, Department of Pediatrics, The Milton S. Hershey Medical Center, Pennsylvania State University, Hershey. Dr Maisels is now with the Department of Pediatrics, William Beaumont Hospital, Royal Oak, Mich.

Footnotes
Accepted for publication July 13, 1989.

Presented in part at the annual meeting of the American Association for Respiratory Care, Dallas, Tex, November 8, 1986, and at the annual meeting of the Society for Pediatric Research, Anaheim, Calif, April 29, 1987.

Reprint requests to Department of Pediatrics, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48072 (Dr Maisels).

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